中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2010年
12期
1-3
,共3页
张晓青%宗成国%栾旭华%赵黎明
張曉青%宗成國%欒旭華%趙黎明
장효청%종성국%란욱화%조려명
尿酸%糖尿病肾病%血脂%肌酐清除率
尿痠%糖尿病腎病%血脂%肌酐清除率
뇨산%당뇨병신병%혈지%기항청제솔
Uric acid%Diabetic nephropathies%Lipid%Creatinine clearance rate
目的 通过检测2型糖尿病(T2DM)患者血尿酸(SUA)、血脂、血肌酐(SCr)等水平,探讨高尿酸血症与相关影响因素及糖尿病肾病发生、发展的关系.方法 根据尿微量白蛋白(mAlb)/肌酐(Cr)水平将102例T2DM患者分为三个亚组:正常白蛋白尿组30例(尿mAlb/Cr＜30μg/mg)、微量白蛋白尿组41例(30μg/mg≤尿mAlb/Cr＜300μg/mg)及临床白蛋白尿组31例(尿mAlb/Cr≥300μg/ms),测定SUA、SCr、糖化血红蛋白(HbA1c)、空腹胰岛索(FINS)、三酰甘油(TG)等指标,计算肌酐清除率(CCr),并与40例对照者(对照组)比较.结果 临床白蛋白尿组SUA水平为(369.3±181.2)μmol/L,显著高于对照组、正常白蛋白尿组、微量白蛋白尿组的(248.6±109.4)、(228.7±104.8)、(296.5±121.4)μmol/L(P＜0.01或＜0.05),且SUA随mAlb/Cr的增加而增加.SUA与SCr、TG呈正相关r=0.369、0.525,P＜0.01),与CCr呈负相关r=-0.389,P＜0.01);多元线性逐步回归分析显示TG与SUA呈正相关(P＜0.05),CCr与SUA呈负相关(P＜0.05),SCr与SUA无相关性.结论 TG和CCr是SUA的独立相关因素,CCr与SUA相关性较SCr更好,高尿酸血症可能参与了T2DM患者糖尿病肾病的发生、发展过程,应尽早干预治疗.
目的 通過檢測2型糖尿病(T2DM)患者血尿痠(SUA)、血脂、血肌酐(SCr)等水平,探討高尿痠血癥與相關影響因素及糖尿病腎病髮生、髮展的關繫.方法 根據尿微量白蛋白(mAlb)/肌酐(Cr)水平將102例T2DM患者分為三箇亞組:正常白蛋白尿組30例(尿mAlb/Cr＜30μg/mg)、微量白蛋白尿組41例(30μg/mg≤尿mAlb/Cr＜300μg/mg)及臨床白蛋白尿組31例(尿mAlb/Cr≥300μg/ms),測定SUA、SCr、糖化血紅蛋白(HbA1c)、空腹胰島索(FINS)、三酰甘油(TG)等指標,計算肌酐清除率(CCr),併與40例對照者(對照組)比較.結果 臨床白蛋白尿組SUA水平為(369.3±181.2)μmol/L,顯著高于對照組、正常白蛋白尿組、微量白蛋白尿組的(248.6±109.4)、(228.7±104.8)、(296.5±121.4)μmol/L(P＜0.01或＜0.05),且SUA隨mAlb/Cr的增加而增加.SUA與SCr、TG呈正相關r=0.369、0.525,P＜0.01),與CCr呈負相關r=-0.389,P＜0.01);多元線性逐步迴歸分析顯示TG與SUA呈正相關(P＜0.05),CCr與SUA呈負相關(P＜0.05),SCr與SUA無相關性.結論 TG和CCr是SUA的獨立相關因素,CCr與SUA相關性較SCr更好,高尿痠血癥可能參與瞭T2DM患者糖尿病腎病的髮生、髮展過程,應儘早榦預治療.
목적 통과검측2형당뇨병(T2DM)환자혈뇨산(SUA)、혈지、혈기항(SCr)등수평,탐토고뇨산혈증여상관영향인소급당뇨병신병발생、발전적관계.방법 근거뇨미량백단백(mAlb)/기항(Cr)수평장102례T2DM환자분위삼개아조:정상백단백뇨조30례(뇨mAlb/Cr＜30μg/mg)、미량백단백뇨조41례(30μg/mg≤뇨mAlb/Cr＜300μg/mg)급림상백단백뇨조31례(뇨mAlb/Cr≥300μg/ms),측정SUA、SCr、당화혈홍단백(HbA1c)、공복이도색(FINS)、삼선감유(TG)등지표,계산기항청제솔(CCr),병여40례대조자(대조조)비교.결과 림상백단백뇨조SUA수평위(369.3±181.2)μmol/L,현저고우대조조、정상백단백뇨조、미량백단백뇨조적(248.6±109.4)、(228.7±104.8)、(296.5±121.4)μmol/L(P＜0.01혹＜0.05),차SUA수mAlb/Cr적증가이증가.SUA여SCr、TG정정상관r=0.369、0.525,P＜0.01),여CCr정부상관r=-0.389,P＜0.01);다원선성축보회귀분석현시TG여SUA정정상관(P＜0.05),CCr여SUA정부상관(P＜0.05),SCr여SUA무상관성.결론 TG화CCr시SUA적독립상관인소,CCr여SUA상관성교SCr경호,고뇨산혈증가능삼여료T2DM환자당뇨병신병적발생、발전과정,응진조간예치료.
Objective To detect the levels of serum uric acid(SUA),lipid and creatinine(SCr) of type 2 diabetes mellitus(T2DM),and discuss the correlation between them and diabetic nephropathy(DN).Methods One hundred and two cases of T2DM patients were selected and divided into three groups based on the level of urine microalbumin(mAlb)/creatinine(Cr):30 cases of N-UAlb group(urine mAlb/Cr＜30μg/mg),41 cases of M-UAlb group(30μg/mg≤urine mAlb/Cr＜300μg/mg)and 31 cases of C-UAlb group(urine mAlb/Cr≥300 μg/mg),detected the SUA,SCr,HbA1c,fasting insulin(FINS),triglyeride(TG)and calculated the creatinine clearance rate(CCr).Selected 40 healthy subjects as control group.Results The SUA level in C-UAlb group[(369.3±181.2)μmol/L]was significantly higher than the other groups [(248.6±109.4)μmol/L in control group;(228.7±104.8)μmol/L in N-UAlb group;(296.5±121.4)μmol/L in M-UAIb group](P＜0.01 or＜0.05),and increased with increment of urine mAlb/Cr.In the whole study population,the Pearson correlation coefficient of SCr,CCr,TG and SUA were 0.369,-0.389.0.525,respectively(P＜0.01).Multiple regression analysis showed that SUA levels in T2DM patients were positively correlated with TG(P＜0.05),and were negatively correlated with CCr(P＜0.05).Conclusions TG and CCr are independent risk factors of SUA.CCr correlates with SUA better than SCr.Diabetic hyperuricemia might affect the process of occurrence and development of DN.There is need for prevention and treatment.
