CAJ | 학술논문

Hedgehog信号通路是调节动物胚胎正常发育的经典信号通路之一,主要由信号分子Hedgehog(Hh)、膜受体Patched(Ptch)、Smoothened(Smo)及某些中间信号传导分子和核转录因子Glioma-associated oncogene homolog(Gli)等组成.Hedgehog信号通路与胰腺胚胎正常发育密切相关,但在正常成熟胰腺组织中无表达或仅低表达.随着对Hedgehog信号通路研究的不断深入,发现Hedgehog信号通路传导异常可导致胰腺癌的发生,并与肿瘤侵袭、转移密切相关.该文对Hedgehog信号通路的构成、传导途径以及在胰腺癌发生中的机制进行综述.
Hedgehog신호통로시조절동물배태정상발육적경전신호통로지일,주요유신호분자Hedgehog(Hh)、막수체Patched(Ptch)、Smoothened(Smo)급모사중간신호전도분자화핵전록인자Glioma-associated oncogene homolog(Gli)등조성.Hedgehog신호통로여이선배태정상발육밀절상관,단재정상성숙이선조직중무표체혹부저표체.수착대Hedgehog신호통로연구적불단심입,발현Hedgehog신호통로전도이상가도치이선암적발생,병여종류침습、전이밀절상관.해문대Hedgehog신호통로적구성、전도도경이급재이선암발생중적궤제진행종술.
The Hedgehog (Hh) signaling pathway plays a key role in the embryonic development, which is formed by the Hedgehog(Hh) , membrane-receptor complex Patched (Ptch) and Smoothened (Smo), multifunctional transcription factors Glioma-associated oncogene homolog (Gli) and other signal molecules. The Hh signaling pathway controls a variety of developing processes, however, no or less expression is observed in the normal pancreas tissues.The mutational activation of the Hh signaling pathway is associated with tumorigenesis and metastasis of the pancreatic cancer. The aim of this review is to present a brief overview of the Hedgehog signaling pathway in the mechanism of the tumorigenesis of the pancreatic cancer.