CAJ | 학술논문

目的应用频域OCT(spectral domain Optical Coherence Tomography,SD-OCT)分析正常人眼黄斑厚度、体积及视盘旁神经纤维的分布情况.方法应用频域OCT对62名124只眼正常人(21～58岁)黄斑及视盘旁进行快速扫描,测量正常眼中心/小凹厚度(Central point thickness,CPT),黄斑部直径为3mm圆形区域内9个分区内平均厚度(Th)及体积(V);同时测量视盘旁直径为3.4mm圆形区域神经纤维分布情况.入组标准:矫正视力20/20,眼压正常,没有已知眼病.结果 124只正常眼中心小凹平均厚度为(215.11±15.475)μm,中心区为(255.56±16.709)μm),黄斑区厚度图呈开口向颞侧的马蹄形,在所有ETDRS区域中,鼻外象限厚度最大(352.87±15.886)μm;中心凹鼻侧厚度及体积大于颞侧(P<0.05);在内环区域,上下方视网膜厚度及体积无明显差异;在外环区域,上下方视网膜厚度及体积差异有统计学意义(P<0.05);视盘旁神经纤维的分布,颞下方神经纤维分布最多,鼻侧神经纤维最少差异有统计学意义.结论应用频域OCT测量,正常人眼黄斑部中心小凹厚度为(215.11±15.475)μm,中央区为(255.56±16.709)μm,神经纤维层厚度与以往时域OCT测量结果基本一致.频域OCT成像清晰,能够精确测量黄斑视网膜厚度及视盘旁神经纤维分布情况,可为临床诊治黄斑及视神经病变提供客观、定量的指标.
목적 응용빈역OCT(spectral domain Optical Coherence Tomography,SD-OCT)분석정상인안황반후도、체적급시반방신경섬유적분포정황.방법 응용빈역OCT대62명124지안정상인(21～58세)황반급시반방진행쾌속소묘,측량정상안중심/소요후도(Central point thickness,CPT),황반부직경위3mm원형구역내9개분구내평균후도(Th)급체적(V);동시측량시반방직경위3.4mm원형구역신경섬유분포정황.입조표준:교정시력20/20,안압정상,몰유이지안병.결과 124지정상안중심소요평균후도위(215.11±15.475)μm,중심구위(255.56±16.709)μm),황반구후도도정개구향섭측적마제형,재소유ETDRS구역중,비외상한후도최대(352.87±15.886)μm;중심요비측후도급체적대우섭측(P<0.05);재내배구역,상하방시망막후도급체적무명현차이;재외배구역,상하방시망막후도급체적차이유통계학의의(P<0.05);시반방신경섬유적분포,섭하방신경섬유분포최다,비측신경섬유최소차이유통계학의의.결론 응용빈역OCT측량,정상인안황반부중심소요후도위(215.11±15.475)μm,중앙구위(255.56±16.709)μm,신경섬유층후도여이왕시역OCT측량결과기본일치.빈역OCT성상청석,능구정학측량황반시망막후도급시반방신경섬유분포정황,가위림상진치황반급시신경병변제공객관、정량적지표.
Objective To determine normal values for macular thickness, volume and peripapillary retinal nerve fiber layer thickness(RNFL)measured by spectral domain Optical Coherence Tomography (SD-OCT)in subjects with no known retinal disease and to examine the relationship of RNFL with macular thickness. Methods Sixty-two healthy adults(124 eyes, 21-58 years old)with no known eye disease,best-corrected visual acuity 20/20, and normal intraocular pressure were enrolled. All subjects underwent a complete ophthalmologic examination to rule out any retinal diseases or glaucoma. All the OCT scans were performed by a single operator, Central point thickness(CPT)and retinal thickness(Th)in 9 Early Treatment Diabetic Retinopathy Study(ETDRS)subfields, including central subfield(CSF), were analyzed. Statistical analyses were carried out using the analysis of variance. RNFL thickness was measured around the optic nerve head using 16 automatically averaged, consecutive circular B-scans with 3.4 mm diameter. The automatically segmented RNFL thickness was divided into 7 segments. Results Overall, the mean CPT was(215.11±15.475)μ m, and mean CSF was(255.56± 16.709)μ m. The macular thickness mapping in normal persons was "horse shoe" shaped open to the temporal side. Among the ETDRS subfields, the outer nasal quadrant had the maximum thickness(352.87± 15.886)μ m. The nasal quadrant had a larger thickness and volume than temporal side(P 0.05); in the inner circle area, there was no difference between the superior and inferior retinal average thickness; on the contrary, there was a significant difference between the superior and inferior retinal average thickness and volume in outer circle area. While the distribution of peripapillary retinal nerve fiber also had marked difference. The inferior-temporally side had the most, while the nasal side had the least. Conclusions Normative values for macular thickness in otherwise healthy eyes ware measured to be(215.11 ±15.475)μ m(CPT)and(255.56± 16.709)μ m(CSF)using commercially available Spectralis SD-OCT. Normal RNFL results with SD-OCT are comparable to those reported with time-domain OCT. Due to the legible imaging characters, the SD-OCT can measure normal macular thickness and the distribution of peripapillary retinal nerve fiber accurately, which can provide objective and quantitative indexs for diagnosis and therapy of macular disease and optical neuropathy.