中华消化杂志
中華消化雜誌
중화소화잡지
Chinese Journal of Digestion
2009年
4期
231-235
,共5页
李卫侠%柴维敏%杜联军%朱乃懿%黄蔚%赵香田%刘玉%乔中伟%徐学勤%杨艳华%谢青%陈克敏
李衛俠%柴維敏%杜聯軍%硃迺懿%黃蔚%趙香田%劉玉%喬中偉%徐學勤%楊豔華%謝青%陳剋敏
리위협%시유민%두련군%주내의%황위%조향전%류옥%교중위%서학근%양염화%사청%진극민
肝硬化%体层摄影术,螺旋计算机%血液灌注
肝硬化%體層攝影術,螺鏇計算機%血液灌註
간경화%체층섭영술,라선계산궤%혈액관주
Liver cirrhosis%Tomography,spiral computed%Hemoperfusion
目的 探讨多层螺旋CT灌注成像在肝纤维化早期诊断中的应用价值.方法 33例受检者接受多层螺旋CT肝脏灌注成像检查,其中11例为无明显肝脏疾病的志愿者(对照组),22例经肝脏穿刺活检证实为肝纤维化患者,根据Ishak评分系统再分为轻度肝纤维化组(10例)和显著肝纤维化组(12例).计算各组的各项灌注指标并进行组间比较.结果 对照组、轻度肝纤维化组和显著肝纤维化组的肝动脉分数(HAF)晕升高趋势,均值分别为(18.49±9.69)%、(19.92±6.01)%、(21.31±7.47)%;平均通过时间(MTT)则呈降低趋势.三组的均值分别为(13.80±2.60)s、(12.35±1.31)s和(12.19±3.33)s.对照组、轻度肝纤维化组和显著肝纤维化组的平均血流量(BF)值分为(107.77±37.80)ml·100 g-1·min-1、(114.54±25.81)ml·100 g-1·min-1和(111.98±19.81)ml·100 g-1·min-1;平均血容量(BV)值分别为(16.61±5.78)ml·100 g-1、(17.07±2.94)ml·100 g-1和(16.42±5.53)ml·100 g-1.统计结果显示各组平均HAF、MTT、BF及BV值的差异无统计学意义(P>0.05).结论 CT肝脏灌注可定量测量各项肝脏血流灌注参数,一些灌注值的变化对肝纤维化分期具有一定程度的参考价值,但尚不能有效地进行肝纤维化的早期诊断.
目的 探討多層螺鏇CT灌註成像在肝纖維化早期診斷中的應用價值.方法 33例受檢者接受多層螺鏇CT肝髒灌註成像檢查,其中11例為無明顯肝髒疾病的誌願者(對照組),22例經肝髒穿刺活檢證實為肝纖維化患者,根據Ishak評分繫統再分為輕度肝纖維化組(10例)和顯著肝纖維化組(12例).計算各組的各項灌註指標併進行組間比較.結果 對照組、輕度肝纖維化組和顯著肝纖維化組的肝動脈分數(HAF)暈升高趨勢,均值分彆為(18.49±9.69)%、(19.92±6.01)%、(21.31±7.47)%;平均通過時間(MTT)則呈降低趨勢.三組的均值分彆為(13.80±2.60)s、(12.35±1.31)s和(12.19±3.33)s.對照組、輕度肝纖維化組和顯著肝纖維化組的平均血流量(BF)值分為(107.77±37.80)ml·100 g-1·min-1、(114.54±25.81)ml·100 g-1·min-1和(111.98±19.81)ml·100 g-1·min-1;平均血容量(BV)值分彆為(16.61±5.78)ml·100 g-1、(17.07±2.94)ml·100 g-1和(16.42±5.53)ml·100 g-1.統計結果顯示各組平均HAF、MTT、BF及BV值的差異無統計學意義(P>0.05).結論 CT肝髒灌註可定量測量各項肝髒血流灌註參數,一些灌註值的變化對肝纖維化分期具有一定程度的參攷價值,但尚不能有效地進行肝纖維化的早期診斷.
목적 탐토다층라선CT관주성상재간섬유화조기진단중적응용개치.방법 33례수검자접수다층라선CT간장관주성상검사,기중11례위무명현간장질병적지원자(대조조),22례경간장천자활검증실위간섬유화환자,근거Ishak평분계통재분위경도간섬유화조(10례)화현저간섬유화조(12례).계산각조적각항관주지표병진행조간비교.결과 대조조、경도간섬유화조화현저간섬유화조적간동맥분수(HAF)훈승고추세,균치분별위(18.49±9.69)%、(19.92±6.01)%、(21.31±7.47)%;평균통과시간(MTT)칙정강저추세.삼조적균치분별위(13.80±2.60)s、(12.35±1.31)s화(12.19±3.33)s.대조조、경도간섬유화조화현저간섬유화조적평균혈류량(BF)치분위(107.77±37.80)ml·100 g-1·min-1、(114.54±25.81)ml·100 g-1·min-1화(111.98±19.81)ml·100 g-1·min-1;평균혈용량(BV)치분별위(16.61±5.78)ml·100 g-1、(17.07±2.94)ml·100 g-1화(16.42±5.53)ml·100 g-1.통계결과현시각조평균HAF、MTT、BF급BV치적차이무통계학의의(P>0.05).결론 CT간장관주가정량측량각항간장혈류관주삼수,일사관주치적변화대간섬유화분기구유일정정도적삼고개치,단상불능유효지진행간섬유화적조기진단.
Objective To evaluate the role of multi-slice CT (MSCT) perfusion in early diagnosis of liver fibrosis. Methods Thirty-three subjects underwent CT perfusion of the liver. Among whom, 11 subjects were volunteers without hepatic disease and the other 22 subjects were pathologically confirmed with liver fibrosis who were further divided into slight (n= 10) and severe (n=12)liver fibrosis according to the lshak system. Parameters of CT perfusion were measured and compared among three groups. Results The mean hepatic arterial fraction in controls, light and severe fibrosis tended to increase with the severity of liver fibrosis[(18. 49 ± 9. 69) %, (19. 92 ± 6.01) % and (21.31±7.47)% ,respectively], and the mean mean transit time tended to decrease with the severity of liver fibrosis [(13.80 ± 2. 60) s, (12.35 ± 1.31) s and (12.19 ± 3.33) s, there was no significant difference in all parameters between any two groups (P>0.05). Conclusions Quantitative measurement of hepatic blood supply can be obtained by CT perfusion. Some parameters will be helpful in staging fibrosis to a certain extent. But its clinical usefulness for the evaluation of the early diagnosis may not be affirmed yet.
