中华消化杂志
中華消化雜誌
중화소화잡지
Chinese Journal of Digestion
2010年
11期
793-797
,共5页
肖英莲%汪安江%杨莉%林金坤%张宁%胡品津%陈旻湖
肖英蓮%汪安江%楊莉%林金坤%張寧%鬍品津%陳旻湖
초영련%왕안강%양리%림금곤%장저%호품진%진민호
胃食管反流病%糜烂性食管炎%非糜烂性反流病%食管联合阻抗-pH监测
胃食管反流病%糜爛性食管炎%非糜爛性反流病%食管聯閤阻抗-pH鑑測
위식관반류병%미란성식관염%비미란성반류병%식관연합조항-pH감측
Gastroesophageal reflux disease%Erosive esophagitis%Non-erosive reflux disease%Esophageal combined multichannel intraluminal impedance monitoring
目的 应用食管联合阻抗-pH监测技术探讨胃食管反流病中非酸反流的比例及其与烧心的相关程度.方法 选取消化专科门诊以烧心为主诉的连续病例,通过上消化道内镜将上述患者分为糜烂性食管炎(EE)组和非糜烂性反流病(NERD)组,并进一步通过24 h食管多通道腔内阻抗-pH监测及雷贝拉唑试验性治疗予以确诊.比较两组的联合阻抗-pH监测指标.结果 EE组36例,NERD组62例.两组患者酸反流次数、酸反流时间百分比差异有统计学意义(P值分别=0.001和0.002).EE组和NERD组中非酸反流次数的百分比分别为37.3%(663/1777)和44.3%(1220/2754),差异有统计学意义(x=21.723,P=0.000).EE组酸反流烧心症状指数阳性、非酸反流烧心症状指数阳性及总反流烧心症状指数阳性的百分比分别为36.1%(13/36)、19.4%(7/36)和55.6%(20/36),NERD组则为27.4%(17/62)、6.4%(4/62)和33.8%(21/62).结论 EE组和NERD组患者中非酸反流次数的比例分别为37.3%及44.3%,非酸反流与烧心关系密切.
目的 應用食管聯閤阻抗-pH鑑測技術探討胃食管反流病中非痠反流的比例及其與燒心的相關程度.方法 選取消化專科門診以燒心為主訴的連續病例,通過上消化道內鏡將上述患者分為糜爛性食管炎(EE)組和非糜爛性反流病(NERD)組,併進一步通過24 h食管多通道腔內阻抗-pH鑑測及雷貝拉唑試驗性治療予以確診.比較兩組的聯閤阻抗-pH鑑測指標.結果 EE組36例,NERD組62例.兩組患者痠反流次數、痠反流時間百分比差異有統計學意義(P值分彆=0.001和0.002).EE組和NERD組中非痠反流次數的百分比分彆為37.3%(663/1777)和44.3%(1220/2754),差異有統計學意義(x=21.723,P=0.000).EE組痠反流燒心癥狀指數暘性、非痠反流燒心癥狀指數暘性及總反流燒心癥狀指數暘性的百分比分彆為36.1%(13/36)、19.4%(7/36)和55.6%(20/36),NERD組則為27.4%(17/62)、6.4%(4/62)和33.8%(21/62).結論 EE組和NERD組患者中非痠反流次數的比例分彆為37.3%及44.3%,非痠反流與燒心關繫密切.
목적 응용식관연합조항-pH감측기술탐토위식관반류병중비산반류적비례급기여소심적상관정도.방법 선취소화전과문진이소심위주소적련속병례,통과상소화도내경장상술환자분위미란성식관염(EE)조화비미란성반류병(NERD)조,병진일보통과24 h식관다통도강내조항-pH감측급뢰패랍서시험성치료여이학진.비교량조적연합조항-pH감측지표.결과 EE조36례,NERD조62례.량조환자산반류차수、산반류시간백분비차이유통계학의의(P치분별=0.001화0.002).EE조화NERD조중비산반류차수적백분비분별위37.3%(663/1777)화44.3%(1220/2754),차이유통계학의의(x=21.723,P=0.000).EE조산반류소심증상지수양성、비산반류소심증상지수양성급총반류소심증상지수양성적백분비분별위36.1%(13/36)、19.4%(7/36)화55.6%(20/36),NERD조칙위27.4%(17/62)、6.4%(4/62)화33.8%(21/62).결론 EE조화NERD조환자중비산반류차수적비례분별위37.3%급44.3%,비산반류여소심관계밀절.
Objective To investigate the prevalence of non-acidic reflux in patients with gastroesophageal reflux disease and its correlation extent with heartburn symptom by 24-hour combined multichannel intraluminal impedance-pH (MII-pH) monitoring. Methods Consecutive patients with chief complain of heartburn in gastrointestinal specialty clinic were enrolled. Patients were divided into erosive esophagitis (EE) group, non-erosive reflux disease (NERD) group after upper gastrointestinal endoscope, further diagnosed with 24-hour combined MII-pH monitoring and rabeprazole test. The MII-pH parameters were compared in these two groups. Results 36 cases of EE and 62 of NERD were enrolled. There was significant difference in acidic reflux frequency and acidic reflux time percentage between these two groups (P=0. 001 and 0. 002). The frequency of non-acidic reflux in EE and NERD groups was 37.3% (663/1777) and 44.3% (1220/2754) respectively (x2 =21. 723,P = 0. 000). The percentage of heartburn symptom positive index in patients with acidic reflux, non-acidic reflux , and total reflux in EE group was 36.1 % (13/36), 19.4 % (7/36) and 55.6%(20/36) respectively, while in NERD group was 27. 4% (17/62), 6.4 % (4/62) and 33.8% (21/62).Conclusion The percentage of non-acidic reflux in EE and NERD groups was 37.3% and 44.3%respectively, and the non-acidic reflux was highly related to heartburn symptom.
