CAJ | 학술논문

目的：了解小儿和成人肾小球疾病病理类型的异同。方法：我院住院的小儿与成人经肾活检术确诊为肾小球疾病的患者4 328例，对其病理类型进行比较。结果：PGN可见14种病理改变，小儿组中的4种类型(MsPGN、IgMN、EnP、MCD)明显多于成人组(均P＜0.01)。成人组有7种类型(IgAN、MN、FSGS、MPGN、FGS、SGN、PSGN)明显多于小儿组(均P＜0.01)。SGN小儿以HSPN(85.0％)占大多数，其次为LN(8.6％)；成人以HFRS(31.7％)较多见，次为LN(30.2％)、HSPN(19.0％)。结论：PGN小儿组病理类型和病变程度均较成人组轻。SGN小儿组病理类型较少，而成人组的病理类型较复杂，与随年龄增长而继发性疾病增多有关。
목적：료해소인화성인신소구질병병리류형적이동。방법：아원주원적소인여성인경신활검술학진위신소구질병적환자4 328례，대기병리류형진행비교。결과：PGN가견14충병리개변，소인조중적4충류형(MsPGN、IgMN、EnP、MCD)명현다우성인조(균P＜0.01)。성인조유7충류형(IgAN、MN、FSGS、MPGN、FGS、SGN、PSGN)명현다우소인조(균P＜0.01)。SGN소인이HSPN(85.0％)점대다수，기차위LN(8.6％)；성인이HFRS(31.7％)교다견，차위LN(30.2％)、HSPN(19.0％)。결론：PGN소인조병리류형화병변정도균교성인조경。SGN소인조병리류형교소，이성인조적병리류형교복잡，여수년령증장이계발성질병증다유관。
Objective:To investigate the differences of pathological change between children and adult patients with glomerulo-pathy. Methods: The pathological types of 4 328 child and adult patients with glomerulopathy diagnosed by biopsy were ret-rospectively analyzed. Results:There were 14 pathological types in PGN. The 4 pathological types (MsPGN, IgMN, EnPand MCD)in child were more than in adults(all P＜0.01). The 7 pathological types(IgAN, MN, FSGS, MPGN,FGS, SGNand PSGN)in adults were more than in children(all P＜0.01). In child patients with SGN,HSPN(85.0% )was most fre-quent,the second was LN(8.6%). In adult patients with SGN, HFRS(31.7% )was most frequent,other types were LN(30.2 % )and HSPN(19.0 %). Conclusion: The pathologic type and change of PGN in children were higher than in adults.The pathologic type of SGN in adults was more complex than in children, which was correlated to increase of age and sec-ondary disease.