CAJ | 학술논문

观察2型糖尿病维吾尔医不同体液证型患者神经内分泌免疫网络有关指标的变化,探讨各体液证型与神经内分泌免疫网络的关系.采用流式细胞术、放射免疫法和液相色谱法等,检测2型糖尿病患者外周血中CD4~+、CD8~+、CD4~+/CD8~+、NK、IL-1β、JL-6、TNF-α、ACTH、CORT、NE和DA水平,并进行分析.结果显示,异常黑胆质型2型糖尿病的构成比为45.40%,几乎与其他3种维医异常体液类型的总和相当.异常黑胆质型T2DM患者组的外周血CD4~+水平低于异常血液质型T2DM组(P＜0.01);异常黑胆质型T2DM患者组血清NK细胞水平低于异常血液质型及异常黏液质型T2DM组(P＜0.01);异常黑胆质型2型糖尿病组IL-1β含量高于异常黏液质型、异常胆液质型和异常血液质型T2DM组(P＜0.05);异常黑胆质型2型糖尿病组IL-6含量高于异常黏液质型及异常胆液质型T2DM组(P＜0.05);异常黑胆质型2型糖尿病组血浆NE含量高于异常血液质型及异常胆液型2型糖尿病组(P＜0.01);不同异常体液型2型糖尿病患者血浆DA含量和血清ACTH及CORT含量在各组间比较无明显差异(P＞0.05).由此得出结论:异常黑胆质型2型糖尿病是T2DM维医体液分型的主要证型.与其他类型T2DM比较,异常黑胆质型T2DM免疫功能更加紊乱,交感神经兴奋更加明显.
관찰2형당뇨병유오이의불동체액증형환자신경내분비면역망락유관지표적변화,탐토각체액증형여신경내분비면역망락적관계.채용류식세포술、방사면역법화액상색보법등,검측2형당뇨병환자외주혈중CD4~+、CD8~+、CD4~+/CD8~+、NK、IL-1β、JL-6、TNF-α、ACTH、CORT、NE화DA수평,병진행분석.결과현시,이상흑담질형2형당뇨병적구성비위45.40%,궤호여기타3충유의이상체액류형적총화상당.이상흑담질형T2DM환자조적외주혈CD4~+수평저우이상혈액질형T2DM조(P＜0.01);이상흑담질형T2DM환자조혈청NK세포수평저우이상혈액질형급이상점액질형T2DM조(P＜0.01);이상흑담질형2형당뇨병조IL-1β함량고우이상점액질형、이상담액질형화이상혈액질형T2DM조(P＜0.05);이상흑담질형2형당뇨병조IL-6함량고우이상점액질형급이상담액질형T2DM조(P＜0.05);이상흑담질형2형당뇨병조혈장NE함량고우이상혈액질형급이상담액형2형당뇨병조(P＜0.01);불동이상체액형2형당뇨병환자혈장DA함량화혈청ACTH급CORT함량재각조간비교무명현차이(P＞0.05).유차득출결론:이상흑담질형2형당뇨병시T2DM유의체액분형적주요증형.여기타류형T2DM비교,이상흑담질형T2DM면역공능경가문란,교감신경흥강경가명현.
To observe the neuro-endocrine-immune system markers of T2DM in different abnormal body fluid syndromes and discuss the relations between abnormal body fluid syndromes and neuroendocrine-immune systems,the levels of Cluster of Differentiation 4+ (CD4~+),Cluster of Differentiation 8+ (CD8~+),Narual Killer cell (NK),Intedeukin-1β(IL-1β),Interleukin-6 (IL-6),Tumor Necrosis Factor-α (TNF-α),Adrenocorticotropic-Hormone (ACTH),Cortisol (CORT),Dopamine (DA),Noradrenaline (NE) were tested by using Flow Cytometer,radioimmunoassay method and Liquid Chromatography.Patients with abnormal savda T2DM make up 45.40% of T2DM,nearly amounting to the total percentage value of other three kind of abnormal body fluids.Compared to the abnormal khan group,the level of CD4~+ was decreased in the abnormal savda group (P＜0.01).Compared to the abnormal khan and belghem group,the level of NK was decreased in the abnormal savda group (P＜0.01).Compared to the abnormal belghem,sepra and khan group,the level of IL-1β was increased in the abnormal savda group (P＜0.05).Compared to the abnormal belghem and sepra group,the level of IL-6 was increased in the abnormal savda group (P＜0.05).Compared to the abnormal khan and sepra group,the level of NE was increased in the abnormal savda group (P＜0.05).There were no significant differences on the levels of DA,ACTH and CORT in patients with different body fluids (P＞0.05).It is concluded that the abnormal savda syndrome is the main syndrome in type-2 diabetes milletus in Uyghur Medicine.Compared with other Uighur abnormal hiht groups in type-2 diabetes,the abnormal savda group has the most unbalanced immune system and its sympathetic nerve is activated mostly.