CAJ | 학술논문

IL-15是一类重要的促炎症因子,在机体固有免疫中发挥着重要的调控作用.类风湿性关节炎、银屑病、系统性红斑狼疮等许多自身免疫性疾病与IL-15的表达异常密切相关.IL-15基因表达存在着复杂的调控机制.目前国内外研究发现多种因素以多种机制参与IL-15基因表达各个阶段的调节,尤其是转录水平的单核及巨噬细胞功能刺激因子调节和转录后水平的两种特异性信号肽调节,以及最近发现的外源性IL-15和短信号肽IL-15对IL-15的负反馈调节.
IL-15시일류중요적촉염증인자,재궤체고유면역중발휘착중요적조공작용.류풍습성관절염、은설병、계통성홍반랑창등허다자신면역성질병여IL-15적표체이상밀절상관.IL-15기인표체존재착복잡적조공궤제.목전국내외연구발현다충인소이다충궤제삼여IL-15기인표체각개계단적조절,우기시전록수평적단핵급거서세포공능자격인자조절화전록후수평적량충특이성신호태조절,이급최근발현적외원성IL-15화단신호태IL-15대IL-15적부반궤조절.
IL-15 is an important pro-inflammatory factor.It plays an important role in natural immunity.Rheumatoid arthritis,psoriasis,systemic lupus erythematosus,and many other autoimmune diseases are closely related to the abnormal expression of IL-15.There is a complex regulatory mechanism in IL-15 gene expression.Recent studies found a variety of factors with different mechanisms involved in IL-15 gene expression regulation in various stages,especially in the level of transcription by monocytes/macrophages-stimulating factor and in the level of post-transcription by two kinds of specific signal peptides.The recent discovery of IL-15 negative feedback regulation by exogenous IL-15 and SSP-IL-15 Was also discussed.