CAJ | 학술논문

目的检测勃起功能障碍(ED)患者的瘦素水平,探讨Leptin在ED患者中的表达及其意义.方法应用酶联免疫吸附试验(ELISA)法分别检测60例ED患者(患者组)及30名健康成人(对照组)清晨空腹血瘦素水平,同时记录所有人的身高、体质量并计算体质量指数( BMI),根据勃起功能国际问卷( IIEF-5)评分将患者组分为轻、中、重3组.结果患者组和对照组瘦素水平与BMI都明显相关；在排除BMI影响的情况下,患者组瘦素值(11.33±5.32) μg/L明显高于对照组(4.41±3.56) μg/L(P＜0.05)；同时轻、中、重3组的瘦素值分别为(6.98±5.19) μg/L、(10.60±8.11) μg/L、(13.90±9.43) μg/L,有明显上升趋势(P＜0.05).结论测定瘦素水平对勃起功能障碍患者的诊断与疗效评估有一定参考价值.
목적 검측발기공능장애(ED)환자적수소수평,탐토Leptin재ED환자중적표체급기의의.방법 응용매련면역흡부시험(ELISA)법분별검측60례ED환자(환자조)급30명건강성인(대조조)청신공복혈수소수평,동시기록소유인적신고、체질량병계산체질량지수( BMI),근거발기공능국제문권( IIEF-5)평분장환자조분위경、중、중3조.결과 환자조화대조조수소수평여BMI도명현상관；재배제BMI영향적정황하,환자조수소치(11.33±5.32) μg/L명현고우대조조(4.41±3.56) μg/L(P＜0.05)；동시경、중、중3조적수소치분별위(6.98±5.19) μg/L、(10.60±8.11) μg/L、(13.90±9.43) μg/L,유명현상승추세(P＜0.05).결론 측정수소수평대발기공능장애환자적진단여료효평고유일정삼고개치.
Objective To investigate the expression and significance of serum Leptin level in erectile dysfunction (ED) patients.Methods Leptin was measured by enzyme linked immunosorbent assay (ELISA) in 60 patients and 30 healthy men.Their body weight and height were measured and BMI was calculated.Sixty out-patients with ED were divided into mild,moderate and severe groups by using IIEF-5 questionnaire.Results Serum leptin levels were correlated with BMI in both groups of patients and healthy men.The leptin concentration in patients ( 11.33 ± 5.32 ) μg/L was significantly higher than in healthy men (4.41 ±3.56) μg/L (P＜0.05).The leptin levels were increased from the mild to the severe ED patients ( P ＜ 0.05 ).Conclusion Human serum leptin level may serve as a marker for diagnosing ED and evaluating the curative effect.