中华肾脏病杂志
中華腎髒病雜誌
중화신장병잡지
2010年
6期
422-426
,共5页
徐潇漪%多景华%罗洋%曾春艳%芮宏亮%徐国宾%王学晶%程虹%辛智利%李文歌%郭岩%谌贻璞
徐瀟漪%多景華%囉洋%曾春豔%芮宏亮%徐國賓%王學晶%程虹%辛智利%李文歌%郭巖%諶貽璞
서소의%다경화%라양%증춘염%예굉량%서국빈%왕학정%정홍%신지리%리문가%곽암%심이박
肾疾病,慢性%患病率%流行病学%少数民族%危险因素
腎疾病,慢性%患病率%流行病學%少數民族%危險因素
신질병,만성%환병솔%류행병학%소수민족%위험인소
Kidney disease,chronic%Prevalence%Epidemiology%Minority%Risk factor
目的 探讨我国内蒙古自治区呼伦贝尔少数民族聚居区成年人群中慢性肾脏病(CKD)患病率及其危险因素.方法 对该地区20岁以上常住居民进行CKD抽样调查,被调查者均检测了尿白蛋白/肌酐比率、血尿(离心后尿沉渣显微镜检查)及估计肾小球滤过率(eGFR,检验血清肌酐后用国人校正的简化MDRD公式计算);并同时调查了CKD的相关危险因素.结果 符合入选条件的被调查者共4522例,白蛋白尿阳性率为7.11%;血尿阳性率为2.64%;eGFR低于60 ml·min-1·(1.73 m2)-1者为2.75%;去除白蛋白尿、血尿及eGFR下降共同存在造成的重复,该地区CKD患病率为12.95%.高血压患病率38.90%,糖代谢异常6.61%,脂代谢异常34.60%,腰围增大24.79%,代谢综合征15.02%.多因素Logistic回归分析及分层分析显示,年龄增加、腰围增大、收缩压升高、空腹血糖升高、血清三酰甘油增高及患代谢综合征与白蛋白尿发生相关;年龄增加、收缩压升高及空腹血糖升高与肾功能下降相关;年龄增加与血尿发生相关.结论 内蒙古自治区呼伦贝尔地区CKD患病率为12.95%.相关危险因素包括年龄增加、腰围增大、高血压、血糖或血脂异常、及代谢综合征.
目的 探討我國內矇古自治區呼倫貝爾少數民族聚居區成年人群中慢性腎髒病(CKD)患病率及其危險因素.方法 對該地區20歲以上常住居民進行CKD抽樣調查,被調查者均檢測瞭尿白蛋白/肌酐比率、血尿(離心後尿沉渣顯微鏡檢查)及估計腎小毬濾過率(eGFR,檢驗血清肌酐後用國人校正的簡化MDRD公式計算);併同時調查瞭CKD的相關危險因素.結果 符閤入選條件的被調查者共4522例,白蛋白尿暘性率為7.11%;血尿暘性率為2.64%;eGFR低于60 ml·min-1·(1.73 m2)-1者為2.75%;去除白蛋白尿、血尿及eGFR下降共同存在造成的重複,該地區CKD患病率為12.95%.高血壓患病率38.90%,糖代謝異常6.61%,脂代謝異常34.60%,腰圍增大24.79%,代謝綜閤徵15.02%.多因素Logistic迴歸分析及分層分析顯示,年齡增加、腰圍增大、收縮壓升高、空腹血糖升高、血清三酰甘油增高及患代謝綜閤徵與白蛋白尿髮生相關;年齡增加、收縮壓升高及空腹血糖升高與腎功能下降相關;年齡增加與血尿髮生相關.結論 內矇古自治區呼倫貝爾地區CKD患病率為12.95%.相關危險因素包括年齡增加、腰圍增大、高血壓、血糖或血脂異常、及代謝綜閤徵.
목적 탐토아국내몽고자치구호륜패이소수민족취거구성년인군중만성신장병(CKD)환병솔급기위험인소.방법 대해지구20세이상상주거민진행CKD추양조사,피조사자균검측료뇨백단백/기항비솔、혈뇨(리심후뇨침사현미경검사)급고계신소구려과솔(eGFR,검험혈청기항후용국인교정적간화MDRD공식계산);병동시조사료CKD적상관위험인소.결과 부합입선조건적피조사자공4522례,백단백뇨양성솔위7.11%;혈뇨양성솔위2.64%;eGFR저우60 ml·min-1·(1.73 m2)-1자위2.75%;거제백단백뇨、혈뇨급eGFR하강공동존재조성적중복,해지구CKD환병솔위12.95%.고혈압환병솔38.90%,당대사이상6.61%,지대사이상34.60%,요위증대24.79%,대사종합정15.02%.다인소Logistic회귀분석급분층분석현시,년령증가、요위증대、수축압승고、공복혈당승고、혈청삼선감유증고급환대사종합정여백단백뇨발생상관;년령증가、수축압승고급공복혈당승고여신공능하강상관;년령증가여혈뇨발생상관.결론 내몽고자치구호륜패이지구CKD환병솔위12.95%.상관위험인소포괄년령증가、요위증대、고혈압、혈당혹혈지이상、급대사종합정.
Objective To investigate the prevalence and risk factors of chronic kidney disease (CKD) in the general adult population in the Hulunbeir Prefecture, Inner Mongolia Autonomous Region where many minorities of north China live. Methods Sampling surveywas performed in the residents aged 20 years and older in the Hulunbeir Prefecture. All the investigated subjects were tested for urinary albumin to creatinine ratio (ACR); hematuria by microscopy of urinary sediment; and GFR estimated by modified MDRD equation for Chinese adults (eGFR). The related risk factors of CKD were also investigated. Results A total of 4522 subjects were enrolled in the study. The prevalence of albuminuria was 7.11％, hematuria was 2.64％ and reduced eGFR [60 ml-min-1·(1.73 m2)-1] was 2.75％. The prevalence of hypertension was 38.90％; hyperglycemia 6.61％; hyperlipidemia 2.72％; increased waist 24.79％ and metabolic syndrome 15.02％. After the subjects with combined microalbuminuria, hematuria and reduced eGFR were excluded, the prevalence of CKD was 12.95％. Logistic regression analysis and stratified analysis showed increased age, increased waist, elevated systolic pressure, hyperglycemia,hypertriglyceridemia and metabolic syndrome were independently associated with albuminuria;increased age, elevated systolic pressure and hyperglycemia were independently associated with reduced eGFR; increased age was independently associated with hematuria. Conclusions The prevalence of adult CKD is 12.95％ in the Hulunbeir Prefecture, Inner Mongolia Autonomous Region. Independent risk factors of CKD include increased age, increased waist, hypertension,abnormal blood glucose or lipid, and metabolic syndrome.
