CAJ | 학술논문

阿尔采末病(Alzheimer sdisease,AD)是一种以进行性认知功能障碍和记忆力损害为主的中枢神经系统退行性疾病.对AD的发病机制存在多种假说,其中氧化应激假说目前越来越受到重视.该文从自由基来源、AD病理特征与氧化应激的关系、相关的动物和临床相关研究、常用抗氧化剂和磷酸二酯酶抑制剂在抗氧化应激方面对AD的治疗作用等,对近年来国内外氧化应激与AD关系的研究进行简要综述.
아이채말병(Alzheimer sdisease,AD)시일충이진행성인지공능장애화기억력손해위주적중추신경계통퇴행성질병.대AD적발병궤제존재다충가설,기중양화응격가설목전월래월수도중시.해문종자유기래원、AD병리특정여양화응격적관계、상관적동물화림상상관연구、상용항양화제화린산이지매억제제재항양화응격방면대AD적치료작용등,대근년래국내외양화응격여AD관계적연구진행간요종술.
Alzheimer's disease(AD)is a progressive neurodegenerative disease characterized by cognition impairment and behavioral abnormalities.While the mechanisms involved in AD remain unclear,various hypotheses have been proposed regarding pathogenesis of AD,among which the oxidative stress hypothesis has attracted more and more attention.In the present article,the relationship between oxidative stress and AD is reviewed,including sources of neuronal oxygen radical generation,the link of oxidative stress to pathogenesis of AD,preclinical and clinical studies of AD,therapeutic effects of antioxidants and phosphodiesterase inhibitors on AD.