CAJ | 학술논문

目的观察在常规罗钙全治疗的基础上,加用针灸和健脾益肾方口服治疗维持性血液透析患者肾性骨病的临床治疗效果.方法对30例患者,分为治疗组(15例),在给予口服罗钙全0.25μg,q.d.基础上,采用针灸(每周3次)加健脾益肾方(2次/d)口服;对照组(15例),罗钙全0.25μg,q.d.口服治疗;连续观察3个月,治疗过程使用的药物包括促红素、透析参数如血流量、透析器及透析机的型号均相同,对两组患者进行血清钙、磷、甲状旁腺素(PTH)、β-微球蛋白、以及血Scr、UA、BUN、HGB、骨痛程度等的比较.结果治疗组表现在全身骨痛及抽筋症状等方面有明显减轻,与对照组相比有统计学意义(P＜0.05);在血清钙、磷、PTH、β-球蛋白浓度改变等方面无统计学意义(P＞0.05).结论在常规罗钙全治疗的基础上,加用针灸和健脾益肾方口服,能明显改善血液透析患者肾性骨病的疼痛程度及抽筋等肌痉挛症状,同时改善血清钙、磷代谢紊乱、降低PTH和β-球蛋白水平,从而治疗肾性骨病.
목적 관찰재상규라개전치료적기출상,가용침구화건비익신방구복치료유지성혈액투석환자신성골병적림상치료효과.방법 대30례환자,분위치료조(15례),재급여구복라개전0.25μg,q.d.기출상,채용침구(매주3차)가건비익신방(2차/d)구복;대조조(15례),라개전0.25μg,q.d.구복치료;련속관찰3개월,치료과정사용적약물포괄촉홍소、투석삼수여혈류량、투석기급투석궤적형호균상동,대량조환자진행혈청개、린、갑상방선소(PTH)、β-미구단백、이급혈Scr、UA、BUN、HGB、골통정도등적비교.결과 치료조표현재전신골통급추근증상등방면유명현감경,여대조조상비유통계학의의(P＜0.05);재혈청개、린、PTH、β-구단백농도개변등방면무통계학의의(P＞0.05).결론 재상규라개전치료적기출상,가용침구화건비익신방구복,능명현개선혈액투석환자신성골병적동통정도급추근등기경련증상,동시개선혈청개、린대사문란、강저PTH화β-구단백수평,종이치료신성골병.
Objective To observe the effect of the Jianpiyishenfang decoction combined with acupuncture and moxibustion and Rocalirol for curing maintenance hemodialysis patients with renal osteodystrophy disease. Methods 30 cases of maintenance hemodialysis(MD)patients were randomly divided into two groups. "treatment group of 15 cages "and "control group of 15 cases".The treatment group took Jianpiyishenfang twice a day,and accepted acupuncture and moxibustion for three times one week combined with Rocalirol,0.25 μg,qd.During the treatment,the drug including EPO,the dialysis parameters,such as blood flowing volume per minute and dialyzer type and hemedialysis machine were all the same.The control group took Rocalirol,0.25 μg,qd,only.3 months'observation was conducted.For the two groups,measuring the changes of Ca2+,P3+,PTH,B-MG,Scr,UA,BUN,HGB and so on was performed.Results The treatment group,which accepted the treatment of Jianpiyishenfang decoction combined with acupuncture and moxibustion and Rocalirol,exhibited a relief of the degree of bone pain and an alleviation of the symptoms of cramp, with the difference being significant(P<0.05).But on the aspects of changes of Ca2+.P3+,PTH,and β-MG data, it showed no dominant difference(P<0.05).Conclusions,The combined treatment of the Jianpiyishenfang decoction with acupuncture and moxibustion and Rocalirol can obviously relieve the degree of bone pain.regulate the balance of Ca2+,P3+ metabolism,and reduce the level of serum PTH and β-MG,SO as to treat the renal osteodystrophy disease.