中国实用眼科杂志
中國實用眼科雜誌
중국실용안과잡지
CHINESE JOURNAL OF PRACTICAL OPHTHALMOLOGY
2009年
3期
301-304
,共4页
陈敏洁%龚岚%孙兴怀%刘祖国%李毓敏%张月琴%赵武令
陳敏潔%龔嵐%孫興懷%劉祖國%李毓敏%張月琴%趙武令
진민길%공람%손흥부%류조국%리육민%장월금%조무령
酮替芬%依美斯汀%季节性变应性结膜炎
酮替芬%依美斯汀%季節性變應性結膜炎
동체분%의미사정%계절성변응성결막염
Ketotifen%Emedastine%Seasonal allergic conjunctivitis
目的 探讨0.025%富马酸酮替芬滴眼液治疗季节性变应性结膜炎患者眼痒、结膜充血的临床疗效.方法 采用多中心、双盲、随机、平行组别的研究方法,将诊断为季节性变应性结膜炎的229例(229只眼)患者随机分为试验组114例,给予进口0.025%富马酸酮替芬滴眼液,对照组115例,给予0.05%依美斯汀滴眼液,均为2次/d,每次1滴,疗程14d.在用药前和用药后(7±1)d,(14±1)d对两组患者的眼痒和结膜充血进行观察评分.结果 用药后(7±1)d以及(14±1)d,酮替芬组和依美斯汀组眼痒、结膜充血评分均明显下降,与基线期相比差异有统计学意义(P<0.05);眼痒和结膜充血下降幅度组间(酮替芬一依美斯汀)差异无统计学意义(P>0.05).结论 进口0.025%富马酸酮替芬滴眼液治疗季节性变应性结膜炎患者的眼痒、结膜充血疗效非劣效于0.05%依美斯汀滴眼液.
目的 探討0.025%富馬痠酮替芬滴眼液治療季節性變應性結膜炎患者眼癢、結膜充血的臨床療效.方法 採用多中心、雙盲、隨機、平行組彆的研究方法,將診斷為季節性變應性結膜炎的229例(229隻眼)患者隨機分為試驗組114例,給予進口0.025%富馬痠酮替芬滴眼液,對照組115例,給予0.05%依美斯汀滴眼液,均為2次/d,每次1滴,療程14d.在用藥前和用藥後(7±1)d,(14±1)d對兩組患者的眼癢和結膜充血進行觀察評分.結果 用藥後(7±1)d以及(14±1)d,酮替芬組和依美斯汀組眼癢、結膜充血評分均明顯下降,與基線期相比差異有統計學意義(P<0.05);眼癢和結膜充血下降幅度組間(酮替芬一依美斯汀)差異無統計學意義(P>0.05).結論 進口0.025%富馬痠酮替芬滴眼液治療季節性變應性結膜炎患者的眼癢、結膜充血療效非劣效于0.05%依美斯汀滴眼液.
목적 탐토0.025%부마산동체분적안액치료계절성변응성결막염환자안양、결막충혈적림상료효.방법 채용다중심、쌍맹、수궤、평행조별적연구방법,장진단위계절성변응성결막염적229례(229지안)환자수궤분위시험조114례,급여진구0.025%부마산동체분적안액,대조조115례,급여0.05%의미사정적안액,균위2차/d,매차1적,료정14d.재용약전화용약후(7±1)d,(14±1)d대량조환자적안양화결막충혈진행관찰평분.결과 용약후(7±1)d이급(14±1)d,동체분조화의미사정조안양、결막충혈평분균명현하강,여기선기상비차이유통계학의의(P<0.05);안양화결막충혈하강폭도조간(동체분일의미사정)차이무통계학의의(P>0.05).결론 진구0.025%부마산동체분적안액치료계절성변응성결막염환자적안양、결막충혈료효비렬효우0.05%의미사정적안액.
Objective To evaluate the efficacy of imported ketotifen fumarate 0.025%ophthalmic solution in alleviating ocular itching and conjunctivai hyperemia in patients with seasonal allergic conjunctivitis.Methods A randomized,double-masked,mnlti-centre,parallel.group clinical study was carried out.Two hundred and twenty-nine patients with seasonal allergic con3unctivitis enrolled into the trial were randomly divided intotwogroups:thetreatmentgroup(n=114)andthe control group(n=115).Patients were either given ketotifen furnarate 0.025%or emedasfine 0.05%,administered twice a day for a treatment period of two weeks.The scores for itching and conjanctival hyperemia of both groups were evaluated at baseline,and on treatment days SeVen(primary efficacy endFIoint)and fourteen.ResultsAt day seven and day fourteen.the scores for itching and conjunctival hyperemia in both groups were reduced significantly.All differences from baseline were statistically significant(P<0.05).And there was no significant difference in efficacy between the ketotifen and the emedastine groups(P>0.05).Conclusion The efficacy of imported ketotifen fumarate 0.025%in alleviating ocular itching and conjunctival hyperemia in patients with seasonal allergic conjunctivitis is not inferior to that ofemedastine 0.05%.