中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2010年
5期
625-627,后插2
,共4页
川芎嗪%罗丹明123%吸收动力学
川芎嗪%囉丹明123%吸收動力學
천궁진%라단명123%흡수동역학
Tetramethylpyrazine%Rhodamine 123%Absorption kinetics
目的 研究川芎嗪对P-gP底物罗丹明123在大鼠小肠的吸收动力学影响. 方法 将24只大鼠分为以下4组:罗丹明123组、川芎嗪与罗丹明123组,川芎嗪预处理后并用罗丹明123合用组、川芎嗪预处理后单用罗丹明123组.采用大鼠在体肠灌流模型和高效液相色谱法考察各组大鼠小肠吸收罗丹明123的速率. 结果 各组大鼠小肠吸收速度常数分别为(0.2690±0.0480)/h、(0.3076±0.0599)/h、(0.3399±0.0424)/h和(0.2957±0.0523)/h.吸收百分率分别为(20.86±3.88)%、(24.33±4.32)%、(25.23±2.51)%和(22.34±2.89)%. 结论 川芎嗪在经过预处理并加入灌流液的条件下能显著提高罗丹明123的吸收速率.
目的 研究川芎嗪對P-gP底物囉丹明123在大鼠小腸的吸收動力學影響. 方法 將24隻大鼠分為以下4組:囉丹明123組、川芎嗪與囉丹明123組,川芎嗪預處理後併用囉丹明123閤用組、川芎嗪預處理後單用囉丹明123組.採用大鼠在體腸灌流模型和高效液相色譜法攷察各組大鼠小腸吸收囉丹明123的速率. 結果 各組大鼠小腸吸收速度常數分彆為(0.2690±0.0480)/h、(0.3076±0.0599)/h、(0.3399±0.0424)/h和(0.2957±0.0523)/h.吸收百分率分彆為(20.86±3.88)%、(24.33±4.32)%、(25.23±2.51)%和(22.34±2.89)%. 結論 川芎嗪在經過預處理併加入灌流液的條件下能顯著提高囉丹明123的吸收速率.
목적 연구천궁진대P-gP저물라단명123재대서소장적흡수동역학영향. 방법 장24지대서분위이하4조:라단명123조、천궁진여라단명123조,천궁진예처리후병용라단명123합용조、천궁진예처리후단용라단명123조.채용대서재체장관류모형화고효액상색보법고찰각조대서소장흡수라단명123적속솔. 결과 각조대서소장흡수속도상수분별위(0.2690±0.0480)/h、(0.3076±0.0599)/h、(0.3399±0.0424)/h화(0.2957±0.0523)/h.흡수백분솔분별위(20.86±3.88)%、(24.33±4.32)%、(25.23±2.51)%화(22.34±2.89)%. 결론 천궁진재경과예처리병가입관류액적조건하능현저제고라단명123적흡수속솔.
Objective To research the effects of Tetramethylpyrazine on the absorption kinetics of rhodamine 123,the substrate of P-gp,in rats intestines.Method Twenty four rats were divided into four groups as following:single given rhodamine 123 in peffusate;rhodamine 123 was given with Tetramethylpyrazine in perfusate;after pretreatments with Tetramethylpyrazine,rhodamine 123 was given with Tetramethylpyrazine in perfusate;after pretreatments with Tetramethylpyrazine,rhodamine 123 was given in perfusate.The absorption kinetics and permeability rate constants(ka)were investigated by the in situ perfusing method in rats and high performance liquid chromatography.Results The result demonstrated that ka were(0.2690±0.0480)/h、(0.3076±0.0599)/h、(0.3399±0.0424)/hand(0.2957±0.0523)/h,respectively;and the uptake rates were(20.86±3.88)%、(24.33±4.32)%、(25.23±2.51)%and(22.34±2.89)%. respectively.Conclusion Tetramethylpyrazine could significantly increase the absorption rate of rhedamine 123 after pretreatments and addition to perfusate.
