CAJ | 학술논문

目的探讨难治性癫痫病灶切除手术患者的临床病理学分型及特点.方法收集清华大学玉泉医院2008年1月至2009年6月,172例难治性癫痫手术治疗患者的病理标本及临床资料.采用HE和免疫组化染色,探讨各种类型癫痫病灶的临床病理学特点.结果经病理诊断,局灶皮质发育不良138例(其中FCD Ⅰ B 115例、FCDⅡA 15例、FCDⅡB 8例)、微发育不良2例、胚胎发育不良性神经上皮瘤4例、Rasmussen脑炎7例、瘢痕脑回16例,节细胞瘤、多小脑回畸形、血管畸形、下丘脑错构瘤及结节性硬化各1例.结论局灶皮质发育不良为引发难治性癫痫最常见病因,其中以FCDⅠ B亚型最为多见.
목적 탐토난치성전간병조절제수술환자적림상병이학분형급특점.방법 수집청화대학옥천의원2008년1월지2009년6월,172례난치성전간수술치료환자적병리표본급림상자료.채용HE화면역조화염색,탐토각충류형전간병조적림상병이학특점.결과 경병리진단,국조피질발육불량138례(기중FCD Ⅰ B 115례、FCDⅡA 15례、FCDⅡB 8례)、미발육불량2례、배태발육불량성신경상피류4례、Rasmussen뇌염7례、반흔뇌회16례,절세포류、다소뇌회기형、혈관기형、하구뇌착구류급결절성경화각1례.결론 국조피질발육불량위인발난치성전간최상견병인,기중이FCDⅠ B아형최위다견.
Objective To discuss the clinicopathologic characteristics of surgically removed tissues in patients with intractable epilepsy. Methods From 2008 to 2009, the histological sections of 172 specimens of cerebral epileptogenic foci, which were acquired by surgery, were performed respectively by HE staining and immunohisto - chemical staining,the characteristics of clinical pathology were also analyzed. Results Of all the 172 cases, according to the pathological features of the epilepto -genic foci, there were 138 focal cortical dysp lasia (FCD) ,including 115 FCD ⅠB, 15 FCD ⅡA and 8 FCD ⅡB, 2 micro cortical dysplasia, 4 dysembryoplastic neuropithelial tumors,7 Rasmussen's encephalitis, 16 ulegyrias; 1 ganglioneuroma; 1 microgyria malformation, 1 vascular malformation, 1 hypothalamic hamartoma, 1 tuberous sclerosis. ConclusionFCD is the most commonly present in intractable epilepsy, and FCDⅠB is most common among the FCD.