CAJ | 학술논문

目的探讨孤立性支气管乳头状瘤(solitary bronchial papilloma,SBP)的临床病理特点、诊断要点及与人乳头状瘤病毒(human papilloma virus,HPV)的感染情况.方法对4例SBP标本进行组织病理学观察和HPV总、HPV16及HPV6/11的检测,并复习临床资料及相关文献.结果 1例老年女性患者肿瘤位于主支气管,为鳞状细胞乳头状瘤,灶性癌变,伴微浸润.3例为混合性鳞状细胞和腺性乳头状瘤,2例伴中度不典型增生,发病年龄25～73岁(平均54岁).肿瘤位于主支气管及段支气管,纤维血管轴心周围被覆复层非角化鳞状上皮及柱状上皮.4例均呈外生性生长,1例伴内翻性生长.HPV检测均为阴性.结论 SBP是发生在成人的一种罕见肺肿瘤,个别病例在鳞状上皮出现异型性的基础上可以发生癌变.建议外科手术完整切除病变,全面观察,以防误诊和漏诊.孤立性支气管乳头状瘤的临床病理特点鲁昌立,许霞,张尚福,张文燕,李俸媛,廖殿英
목적 탐토고립성지기관유두상류(solitary bronchial papilloma,SBP)적림상병리특점、진단요점급여인유두상류병독(human papilloma virus,HPV)적감염정황.방법 대4례SBP표본진행조직병이학관찰화HPV총、HPV16급HPV6/11적검측,병복습림상자료급상관문헌.결과 1례노년녀성환자종류위우주지기관,위린상세포유두상류,조성암변,반미침윤.3례위혼합성린상세포화선성유두상류,2례반중도불전형증생,발병년령25～73세(평균54세).종류위우주지기관급단지기관,섬유혈관축심주위피복복층비각화린상상피급주상상피.4례균정외생성생장,1례반내번성생장.HPV검측균위음성.결론 SBP시발생재성인적일충한견폐종류,개별병례재린상상피출현이형성적기출상가이발생암변.건의외과수술완정절제병변,전면관찰,이방오진화루진.고립성지기관유두상류적림상병리특점로창립,허하,장상복,장문연,리봉원,료전영
Purpose To explore the clinicopathological features, differential diagnosis of solitary bronchial papilloma, and its relation with and human papilloma virus infection.Methods Four cases of SBP were studied by routine histologic,immunohistochemical staining and in situ hybridization, together with review of the literature.Results One of four lesions was squamous cell papilloma, with focal malignant change of squamous cell carcinoma with microinvasion. The case was an old woman and the cancer located in central bronchus. Others were mixed squamous cell and glandular papilloma, and two cases with features of moderate cytologic atypia. The age ranged from 25 to 73 years (average 54), and tumors were located in the bronchi and segmental bronchi. Papillary arborizing connective tissue stalks were lined by both squamous and glandular epithelium. Four papillomas were exophytic, with one case inverted partly. Four cases were examined for HPV DNA and all were negative.Conclusions SBP in adults is a rare lung neoplasm. Based on uncommon cases association with malignant change, all endobronchial papillomas should be completely excised.