CAJ | 학술논문

目的研究睡眠剥夺后类比推理认知功能改变在功能性磁共振成像上的个体差异表现.方法对30例健康志愿者(男性18例,女性12例,平均年龄40岁)进行2次类比推理功能磁共振成像扫描,分别于正常睡眠情况下和睡眠剥夺24小时后,扫描顺序是制衡的.扫描后根据参与者的行为学表现(反应时间与错误率)分别将其分成睡眠剥夺易损组及睡眠剥夺拮抗组,再回顾分析功能性磁共振成像上个体差异表现.数据处理由统计参数图及功能性神经影像分析软件完成.结果正常睡眠情况下,睡眠剥夺易损组的脑活动较睡眠剥夺拮抗组明显减少；睡眠剥夺后,易损组的脑活动显著减少,而睡眠剥夺拮抗组脑活动显著增加.结论不同人群对睡眠剥夺后的人脑反应不尽相同；磁共振成像可能成为睡眠剥夺易损性的一种预测手段.
목적 연구수면박탈후류비추리인지공능개변재공능성자공진성상상적개체차이표현.방법 대30례건강지원자(남성18례,녀성12례,평균년령40세)진행2차류비추리공능자공진성상소묘,분별우정상수면정황하화수면박탈24소시후,소묘순서시제형적.소묘후근거삼여자적행위학표현(반응시간여착오솔)분별장기분성수면박탈역손조급수면박탈길항조,재회고분석공능성자공진성상상개체차이표현.수거처이유통계삼수도급공능성신경영상분석연건완성.결과 정상수면정황하,수면박탈역손조적뇌활동교수면박탈길항조명현감소；수면박탈후,역손조적뇌활동현저감소,이수면박탈길항조뇌활동현저증가.결론 불동인군대수면박탈후적인뇌반응불진상동；자공진성상가능성위수면박탈역손성적일충예측수단.
Objective To investigate individual differences in cerebral hemodynamic response to analogy following sleep deprivation (SD). Methods 30 subjects were scanned twice with functional magnetic resonance imaging (fMRI) at a counter-balanced order after a normal night of sleep (rested state) , and 24 hours of SD state. Subjects performed analogy tasks alternated with a control tasks during the fMRI sean that lasted 12 minutes and 48 seconds. Based on individual behavioral performance after SD, subjects were separated into two subgroups-SD vulnerable (SDV) and SD resilient (SDR) groups. Subgroup data were reanalyzed with Statistical Parametric Mapping (SPM) and Analysis of Functional Neurolmages (AFNI). Results At the rested baseline, the brain activation induced by analogy in the SDR group was more than that in the SDV group. After SD,the brain became less responsive in the SDV group but more aetive in the SDR group, although similar patterns of brain activation were observed in both the rested and SD states. Conclusion Individuals respond to SD differently, fMRI at normal sleep baseline may be useful in predicting the vulnerability of SD.