国际外科学杂志
國際外科學雜誌
국제외과학잡지
INTERNATIONAL JOURNAL OF SURGERY
2011年
7期
458-461,505
,共5页
胃肿瘤%Bcl-w%基质金属蛋白-2%预后
胃腫瘤%Bcl-w%基質金屬蛋白-2%預後
위종류%Bcl-w%기질금속단백-2%예후
Stomach neoplasms%Bcl-w%MMP-2%Prognosis
目的 探讨B细胞淋巴因子-w(Bcl-w)在胃癌中的表达与预后的关系.方法 通过免疫组化SP法,检测100例胃癌组织中Bcl-w和MMP-2(基质金属蛋白-2)的表达.结果 (1)100例胃癌中Bcl-w和MMP-2表达的阳性率分别为69.0%、77.0%;(2)胃癌组织中Bcl-w和MMP-2的表达与肿瘤的大小、浸润深度、组织分化程度和淋巴结转移正相关(P<0.05);(3)胃癌组织中Bcl-w表达与MMP-2表达显著相关(P=0.002);(4)Bcl-w阳性患者5年生存率和总体生存率低于Bcl-w阴性患者.结论 (1)Bcl-w在抑制胃癌细胞凋亡、促进胃癌侵袭转移中发挥重要的作用;(2)Bcl-w在胃癌中的表达与预后负相关,可作为胃癌预后的评价指标.
目的 探討B細胞淋巴因子-w(Bcl-w)在胃癌中的錶達與預後的關繫.方法 通過免疫組化SP法,檢測100例胃癌組織中Bcl-w和MMP-2(基質金屬蛋白-2)的錶達.結果 (1)100例胃癌中Bcl-w和MMP-2錶達的暘性率分彆為69.0%、77.0%;(2)胃癌組織中Bcl-w和MMP-2的錶達與腫瘤的大小、浸潤深度、組織分化程度和淋巴結轉移正相關(P<0.05);(3)胃癌組織中Bcl-w錶達與MMP-2錶達顯著相關(P=0.002);(4)Bcl-w暘性患者5年生存率和總體生存率低于Bcl-w陰性患者.結論 (1)Bcl-w在抑製胃癌細胞凋亡、促進胃癌侵襲轉移中髮揮重要的作用;(2)Bcl-w在胃癌中的錶達與預後負相關,可作為胃癌預後的評價指標.
목적 탐토B세포림파인자-w(Bcl-w)재위암중적표체여예후적관계.방법 통과면역조화SP법,검측100례위암조직중Bcl-w화MMP-2(기질금속단백-2)적표체.결과 (1)100례위암중Bcl-w화MMP-2표체적양성솔분별위69.0%、77.0%;(2)위암조직중Bcl-w화MMP-2적표체여종류적대소、침윤심도、조직분화정도화림파결전이정상관(P<0.05);(3)위암조직중Bcl-w표체여MMP-2표체현저상관(P=0.002);(4)Bcl-w양성환자5년생존솔화총체생존솔저우Bcl-w음성환자.결론 (1)Bcl-w재억제위암세포조망、촉진위암침습전이중발휘중요적작용;(2)Bcl-w재위암중적표체여예후부상관,가작위위암예후적평개지표.
Objective To discuss the meaning and association with prognosis of Bcl-w expression in gastric carcinoma. Methods By Immunohistochemistry( SP) method was used to detect the expression of Bcl-w and MMP-2 in 100 cases of human gastric carcinoma. Results (1) Among 100 cases of stomach carcinoma, Bcl-w and MMP-2 positive expression rates were respectively 69. 0% , 77. 0% ; (2) The Bcl-w and MMP-2 expression in gastric carcinoma was positively associated with tumor size, invasive depth, histology differentiation and lymph node metastasis(P<0.05) ;(3)The expression of Bcl-w was significantly correlated with MMP-2 in gastric carcinomas (P =0.002) ; (4) Five years survival rates and overall survival of Bclw-positive patients were lower than the Bcl-w -negative patients. Conclusions (1)Bcl-w plays an important role in inhibiting apoptosis of gastric cancer and promoting gastric cancer invasion; (2) Bcl-w-positive expression patients have a bad prognosis and Bcl-w expression in gastric carcinoma can be regarded as a prognosis evaluation index.
