国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2009年
16期
28-31
,共4页
环氧化酶-2%P53蛋白%非小细胞肺癌(NSCLC)
環氧化酶-2%P53蛋白%非小細胞肺癌(NSCLC)
배양화매-2%P53단백%비소세포폐암(NSCLC)
NSCLC%COX-2%P53 proteins
目的 研究环氧化酶-2(COX-2)和P53蛋白在非小细胞肺癌(NSCLC)组织和癌旁组织中表达情况,探讨其在NSCLC的发生、发展中的作用.方法 应用免疫组化SP方法,检测NSCLC组织(40例)和癌旁组织(40例)中COX-2及P53蛋白表达情况.结果 COX-2及P53蛋白在NSCIE组织中的表达显著高于癌旁组织.COX-2在NSCLC组织中的表达与组织类型、分化程度、肿瘤大小、临床分期及淋巴结转移密切相关;在腺癌中的表达明显高于鳞癌,且随着肿瘤分化程度越低、肿瘤体积增大、分期越高及淋巴结转移增多,COX-2表达阳性率越高.P53蛋白在NSCLC组织中的表达与淋巴结转移密切相关,随着肿瘤淋巴结转移增多,P53蛋白表达阳性率越高.P53的表达与COX-2正相关,P＜0.01.结论 COX-2及P53蛋白在NSCLC组织中呈高表达,它们在非小细胞肺癌的发生、发展过程中起重要作用,有助于判断NSCLC的发展、淋巴结转移及其预后.
目的 研究環氧化酶-2(COX-2)和P53蛋白在非小細胞肺癌(NSCLC)組織和癌徬組織中錶達情況,探討其在NSCLC的髮生、髮展中的作用.方法 應用免疫組化SP方法,檢測NSCLC組織(40例)和癌徬組織(40例)中COX-2及P53蛋白錶達情況.結果 COX-2及P53蛋白在NSCIE組織中的錶達顯著高于癌徬組織.COX-2在NSCLC組織中的錶達與組織類型、分化程度、腫瘤大小、臨床分期及淋巴結轉移密切相關;在腺癌中的錶達明顯高于鱗癌,且隨著腫瘤分化程度越低、腫瘤體積增大、分期越高及淋巴結轉移增多,COX-2錶達暘性率越高.P53蛋白在NSCLC組織中的錶達與淋巴結轉移密切相關,隨著腫瘤淋巴結轉移增多,P53蛋白錶達暘性率越高.P53的錶達與COX-2正相關,P＜0.01.結論 COX-2及P53蛋白在NSCLC組織中呈高錶達,它們在非小細胞肺癌的髮生、髮展過程中起重要作用,有助于判斷NSCLC的髮展、淋巴結轉移及其預後.
목적 연구배양화매-2(COX-2)화P53단백재비소세포폐암(NSCLC)조직화암방조직중표체정황,탐토기재NSCLC적발생、발전중적작용.방법 응용면역조화SP방법,검측NSCLC조직(40례)화암방조직(40례)중COX-2급P53단백표체정황.결과 COX-2급P53단백재NSCIE조직중적표체현저고우암방조직.COX-2재NSCLC조직중적표체여조직류형、분화정도、종류대소、림상분기급림파결전이밀절상관;재선암중적표체명현고우린암,차수착종류분화정도월저、종류체적증대、분기월고급림파결전이증다,COX-2표체양성솔월고.P53단백재NSCLC조직중적표체여림파결전이밀절상관,수착종류림파결전이증다,P53단백표체양성솔월고.P53적표체여COX-2정상관,P＜0.01.결론 COX-2급P53단백재NSCLC조직중정고표체,타문재비소세포폐암적발생、발전과정중기중요작용,유조우판단NSCLC적발전、림파결전이급기예후.
Objective By detecting the expression of COX-2 and P53 proteins in the tissue of non-small cell lung caneer(NSCLC)and paracaneerous tissues,We studied the effects of COX-2 and P53 proteins and the correlation between COX-2 and P53 proteins.Methods The expression of COX-2 and P53 proteins was detected in NSCLC and paracancer tissues of NSCLC by immunohistochemical method(SP).Results The rate of positive expression of COX-2 and P53 proteins was higher in the tissue of NSCLC than those in paracancerous tissue of NSCLC.The level of expression of COX-2 protein in NSCLC was relative to the pathological types,histoiogic classes,the size of tumor,clinical stages and metastatic lymphonode.The worse histologic classes,the later clinical stage,the bigger tumor and the more metastatic lymphonode,the higher rate was the positive expression of COX-2 protein.The rate of expression of COX-2 protein in adenocarcinoma was higher than in squamous cancer.The degree of expression of P53 protein in NSCLC was relative to the metastatic lymphonode.The level of expression of COX-2 and P53 was closely related to each other.Conclusions COX-2 and P53 proteins could play important roles in oncogenesis and progression of NSCLC.Detection the level of COX-2 and P53 proteins expression might be useful to judge the stage of disease and lymphonede metastasis of NSCLC,and to predict the prognosis of patiems with NSCLC.
