中华行为医学与脑科学杂志
中華行為醫學與腦科學雜誌
중화행위의학여뇌과학잡지
CHINESE JOURNAL OF BEHAVIORAL MEDICINE AND BRAIN SCIENCE
2012年
1期
40-43
,共4页
边缘性人格障碍%抑郁症%疗效%对照研究
邊緣性人格障礙%抑鬱癥%療效%對照研究
변연성인격장애%억욱증%료효%대조연구
Borderline personality disorder%Depression%Clinical effects%Matched study
目的 探讨有边缘性人格障碍倾向的抑郁症与单纯抑郁症患者之间短期临床疗效的差异.方法 采用17项汉密尔顿抑郁量表(HAMD17)、14项汉密尔顿焦虑量表(HAMA14)在治疗前、治疗后第2,4周末分别对22例有边缘性人格障碍倾向的抑郁症患者(BPD组)和22例单纯抑郁症患者(对照组)进行评定.结果 第2周末,BPD组HAMD17总分、情绪因子分和认知障碍因子分分别为(15.5 ±4.50)分、(6.32±1.70)分、(1.09 ±0.75)分,高于对照组[分别为(11.7±3.75)分、(4.77±2.18)分、(0.59±0.73)分],均差异有统计学意义(均P＜ 0.05)；第4周末,HAMD17总分、情绪因子分、睡眠因子分、精神焦虑因子分、躯体焦虑因子分、认知障碍因子分分别为(11.73±4.26)分,(5.41±2.13)分、(1.68±1.17)分、(1.91±.92)分、(1.95±1.10)分、(0.73±0.63)分,高于单纯抑郁组[分别为(5.91±2.74)分、(3.00±1.54)分、(0.77±.69)分、(1.05±0.38)分、(0.82±0.85)分、(0.18±0.40)分],均差异有统计学意义(均P＜0.05)；BPD组与对照组HAMA14总分减分和各因子分减分在第2,4周末差异无统计学意义(均P＞0.05)；第4周末,BPD组HAMD17、HAMA14总分减分率[分别为(50±16)％、(58±12)％],低于对照组分别为[(74±11)％、(74±10)％],均差异有统计学意义(均P＜0.05)；BPD组与对照组在HAMD17疗效上的差异有统计学意义(P＜0.05).结论 有边缘性人格障碍倾向会影响抑郁症临床症状的缓解.
目的 探討有邊緣性人格障礙傾嚮的抑鬱癥與單純抑鬱癥患者之間短期臨床療效的差異.方法 採用17項漢密爾頓抑鬱量錶(HAMD17)、14項漢密爾頓焦慮量錶(HAMA14)在治療前、治療後第2,4週末分彆對22例有邊緣性人格障礙傾嚮的抑鬱癥患者(BPD組)和22例單純抑鬱癥患者(對照組)進行評定.結果 第2週末,BPD組HAMD17總分、情緒因子分和認知障礙因子分分彆為(15.5 ±4.50)分、(6.32±1.70)分、(1.09 ±0.75)分,高于對照組[分彆為(11.7±3.75)分、(4.77±2.18)分、(0.59±0.73)分],均差異有統計學意義(均P＜ 0.05)；第4週末,HAMD17總分、情緒因子分、睡眠因子分、精神焦慮因子分、軀體焦慮因子分、認知障礙因子分分彆為(11.73±4.26)分,(5.41±2.13)分、(1.68±1.17)分、(1.91±.92)分、(1.95±1.10)分、(0.73±0.63)分,高于單純抑鬱組[分彆為(5.91±2.74)分、(3.00±1.54)分、(0.77±.69)分、(1.05±0.38)分、(0.82±0.85)分、(0.18±0.40)分],均差異有統計學意義(均P＜0.05)；BPD組與對照組HAMA14總分減分和各因子分減分在第2,4週末差異無統計學意義(均P＞0.05)；第4週末,BPD組HAMD17、HAMA14總分減分率[分彆為(50±16)％、(58±12)％],低于對照組分彆為[(74±11)％、(74±10)％],均差異有統計學意義(均P＜0.05)；BPD組與對照組在HAMD17療效上的差異有統計學意義(P＜0.05).結論 有邊緣性人格障礙傾嚮會影響抑鬱癥臨床癥狀的緩解.
목적 탐토유변연성인격장애경향적억욱증여단순억욱증환자지간단기림상료효적차이.방법 채용17항한밀이돈억욱량표(HAMD17)、14항한밀이돈초필량표(HAMA14)재치료전、치료후제2,4주말분별대22례유변연성인격장애경향적억욱증환자(BPD조)화22례단순억욱증환자(대조조)진행평정.결과 제2주말,BPD조HAMD17총분、정서인자분화인지장애인자분분별위(15.5 ±4.50)분、(6.32±1.70)분、(1.09 ±0.75)분,고우대조조[분별위(11.7±3.75)분、(4.77±2.18)분、(0.59±0.73)분],균차이유통계학의의(균P＜ 0.05)；제4주말,HAMD17총분、정서인자분、수면인자분、정신초필인자분、구체초필인자분、인지장애인자분분별위(11.73±4.26)분,(5.41±2.13)분、(1.68±1.17)분、(1.91±.92)분、(1.95±1.10)분、(0.73±0.63)분,고우단순억욱조[분별위(5.91±2.74)분、(3.00±1.54)분、(0.77±.69)분、(1.05±0.38)분、(0.82±0.85)분、(0.18±0.40)분],균차이유통계학의의(균P＜0.05)；BPD조여대조조HAMA14총분감분화각인자분감분재제2,4주말차이무통계학의의(균P＞0.05)；제4주말,BPD조HAMD17、HAMA14총분감분솔[분별위(50±16)％、(58±12)％],저우대조조분별위[(74±11)％、(74±10)％],균차이유통계학의의(균P＜0.05)；BPD조여대조조재HAMD17료효상적차이유통계학의의(P＜0.05).결론 유변연성인격장애경향회영향억욱증림상증상적완해.
Objective To explore the borderline personality disorder(BPD) tendency happened in depressive patients and to determine the effects of BPD tendency in remission.Methods Depressive patients with BPD tendency (BPD group,n =22)and pure depressive patients (control group,n =22 ) were assessed with Hamilton depression scale (HAMD)and Hamilton anxiety scale(HAMA) at baseline and on weeks 2,4.Results On week 2,the total score of HAMD,two factors' ( emotion and cognitive disorder) scores of HAMD of the BPD group ( ( 15.5 ±4.50),(6.32 ± 1.70),( 1.09 ± 0.75 ) respectively) significantly higher than the counterparts of the control group,which were ( 11.7 ± 3.75 ),(4.77 ± 2.18 ),( 0.59 ± 0.73 ) respectively ( all P ＜ 0.05 ).And on week 4,the total score of HAMD and all five factors' scores of HAMD of the BPD group were ( ( 11.73 ± 4.26 ),( 5.41 ± 2.13 ),( 1.68 ± 1.17),( 1.91 ± 0.92 ),( 1.95 ± 1.10),(0.73 ± 0.63 ) respectively) ) significantly higher than the counterparts of the control group,which were (5.91 ± 2.74 ),( 3.00 ± 1.54 ),(0.77 ± 0.69 ),( 1.05 ± 0.38),(0.82 ± 0.85 ),(0.18 ± 0.40) respectively ( all P ＜ 0.05 ).The control group significantly exceed the BPD group on the total score reduction ratio of HAMD and HAMA ( all P＜ 0.05 ).They have significant difference on clinical effects (P ＜ 0.05 ).Conclusion The borderline personality disorder tendency in depression affects clinical symptoms remission.
