CAJ | 학술논문

带状疱疹是一种由潜伏在脊髓后根神经节或脑神经的感觉神经节中的水痘-带状疱疹病毒再激活而导致的皮肤病,其发生与水痘-带状疱疹病毒特异性的细胞免疫功能下降有关.为高危人群接种水痘-带状疱疹病毒特异性细胞免疫的带状疱疹疫苗,可以有效的降低带状疱疹的发病率和疾病的严重程度.带状疱疹发生后,应及早应用抗病毒药物及合适的止痛治疗来缓解患者的临床症状,并预防后遗神经痛的发生.通过对带状疱疹患者T细胞免疫机制的深入研究,为免疫治疗提供理论依据.
대상포진시일충유잠복재척수후근신경절혹뇌신경적감각신경절중적수두-대상포진병독재격활이도치적피부병,기발생여수두-대상포진병독특이성적세포면역공능하강유관.위고위인군접충수두-대상포진병독특이성세포면역적대상포진역묘,가이유효적강저대상포진적발병솔화질병적엄중정도.대상포진발생후,응급조응용항병독약물급합괄적지통치료래완해환자적림상증상,병예방후유신경통적발생.통과대대상포진환자T세포면역궤제적심입연구,위면역치료제공이론의거.
Herpes zoster is a skin disease caused by the reactivation of latent varicella zoster virus (VZV)in the posterior root ganglia of spinal nerves or sensory ganglia of cranial nerves.It is associated with a decline in VZV-specific cell-mediated immunity.To boost VZV-specific cell-mediated immunity via immunizing with VZV-targeted vaccines may reduce the incidence and severity of herpes zoster in high-risk populations.Once herpes zoster develops, antivirals and appropriate analgesics should be administrated as early as possible to relieve symptoms and prevent the development of post-herpetic neuralgia.Further research into the mechanisms of T lymphocyte-mediated immunity in herpes zoster may provide a solid theoretical basis for the immunotherapy of herpes zoster.