国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2012年
8期
608-613
,共6页
肺纤维化%间充质干细胞%免疫调节
肺纖維化%間充質榦細胞%免疫調節
폐섬유화%간충질간세포%면역조절
Pulmonary fibrosis%Mesenchymal stem cell%Immunomodulation
间质性肺纤维化是由各种不同原因引起的累及肺间质、肺泡、细支气管的肺部弥漫性疾病,其以非特异性肺泡炎伴肺间质纤维化为共同病理改变,因发病机制不甚清楚,迄今为止尚无有效的治疗药物与方法.间充质干细胞由于它特殊的免疫学特征诸如低免疫原性和免疫调节功能,为间质性肺纤维化的治疗带来了希望的曙光.此综述为以后临床试验研究提供方向和思路.
間質性肺纖維化是由各種不同原因引起的纍及肺間質、肺泡、細支氣管的肺部瀰漫性疾病,其以非特異性肺泡炎伴肺間質纖維化為共同病理改變,因髮病機製不甚清楚,迄今為止尚無有效的治療藥物與方法.間充質榦細胞由于它特殊的免疫學特徵諸如低免疫原性和免疫調節功能,為間質性肺纖維化的治療帶來瞭希望的曙光.此綜述為以後臨床試驗研究提供方嚮和思路.
간질성폐섬유화시유각충불동원인인기적루급폐간질、폐포、세지기관적폐부미만성질병,기이비특이성폐포염반폐간질섬유화위공동병리개변,인발병궤제불심청초,흘금위지상무유효적치료약물여방법.간충질간세포유우타특수적면역학특정제여저면역원성화면역조절공능,위간질성폐섬유화적치료대래료희망적서광.차종술위이후림상시험연구제공방향화사로.
The interstitial pulmonary fibrosis is a group of interstitial lung diseases characterized by varying patterns of inflammation and fibrosis.It is associated with an extremely poor prognosis for survival in most patients. Bone marrow-derived mesenchymal stem cells have immunomodulatory properties and bring first light of morning for curing interstitial pulmonary fibrosis.The review concludes with a discussion of future research directions required for potential clinical trials.
