中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2010年
4期
33-35
,共3页
消炎药,非甾类%上消化道出血
消炎藥,非甾類%上消化道齣血
소염약,비치류%상소화도출혈
Anti-inflammatory agents,non-steroidal%Upper gastrointestinal bleeding
目的 探讨非甾体抗炎药(NSAIDs)致上消化道出血的临床特点及相关原因.方法 调查上消化道出血528例患者的临床资料,根据入院前有无服用NSAIDs史将患者分为NSAIDs组(116例)和非NSAIDs组(412例),对两组患者的临床资料进行分析比较.结果 两组患者在性别构成、是否有吸烟史、是否有溃疡史等方面比较差异无统计学意义(P>0.05);NSAIDs组患者的年龄(57.4±12.1)岁,有幽门螺杆菌感染史者占65.5%(76/116),均较非NSAIDs组的(44.6±11.9)岁、25.0%(103/412)高(P<0.01);糜烂、多发、复合型溃疡病灶在NSAIDs组更多见(P<0.01或<0.05).结论 应加强对NSAIDs相关性上消化道出血临床特点的认识,尽量减少NSAIDs的不良反应.
目的 探討非甾體抗炎藥(NSAIDs)緻上消化道齣血的臨床特點及相關原因.方法 調查上消化道齣血528例患者的臨床資料,根據入院前有無服用NSAIDs史將患者分為NSAIDs組(116例)和非NSAIDs組(412例),對兩組患者的臨床資料進行分析比較.結果 兩組患者在性彆構成、是否有吸煙史、是否有潰瘍史等方麵比較差異無統計學意義(P>0.05);NSAIDs組患者的年齡(57.4±12.1)歲,有幽門螺桿菌感染史者佔65.5%(76/116),均較非NSAIDs組的(44.6±11.9)歲、25.0%(103/412)高(P<0.01);糜爛、多髮、複閤型潰瘍病竈在NSAIDs組更多見(P<0.01或<0.05).結論 應加彊對NSAIDs相關性上消化道齣血臨床特點的認識,儘量減少NSAIDs的不良反應.
목적 탐토비치체항염약(NSAIDs)치상소화도출혈적림상특점급상관원인.방법 조사상소화도출혈528례환자적림상자료,근거입원전유무복용NSAIDs사장환자분위NSAIDs조(116례)화비NSAIDs조(412례),대량조환자적림상자료진행분석비교.결과 량조환자재성별구성、시부유흡연사、시부유궤양사등방면비교차이무통계학의의(P>0.05);NSAIDs조환자적년령(57.4±12.1)세,유유문라간균감염사자점65.5%(76/116),균교비NSAIDs조적(44.6±11.9)세、25.0%(103/412)고(P<0.01);미란、다발、복합형궤양병조재NSAIDs조경다견(P<0.01혹<0.05).결론 응가강대NSAIDs상관성상소화도출혈림상특점적인식,진량감소NSAIDs적불량반응.
Objective To investigate the clinical features and the correlated reason of upper gastrointestinal bleeding (UGIB) induced by non-steroidal anti-inflammatory drugs (NSAIDs). Methods Five hundred and twenty-eight patients were divided into two groups according to consumption of NSAIDs in the week previous to the onset of bleeding, 116 cases were in NSAIDs group and 412 cases were in non-NSAIDs group. The clinical data was analysed and compared between two groups. Results There was no significant difference in sex, smoking history, and ulcer history between two groups (P> 0.05). The average age was (57.4 ± 12.1) years old and the infection of Hp was 65.5% (76/116) in NSAIDs group, and they were higher than those in non-NSA1Ds group [(44.6 ± 11.9) years old and 25.0% (103/412)](P < 0.01). More gastric ulcer and complex ulcer was seen in NSAIDs group (P <0.01 or <0.05). Conclusion Recognition about the clinical characteristics of NSAIDs relevance UGIB should be strengthened, and side effect of NSAIDs should be reduced as far as possible.
