中华全科医师杂志
中華全科醫師雜誌
중화전과의사잡지
CHINESE JOURNAL OF GENERAL PRACTITIONERS
2008年
7期
483-485
,共3页
杜培宜%黄北春%杜松%赵秀芹%彭静%李三纪
杜培宜%黃北春%杜鬆%趙秀芹%彭靜%李三紀
두배의%황북춘%두송%조수근%팽정%리삼기
甲状腺疾病%丙二醛
甲狀腺疾病%丙二醛
갑상선질병%병이철
Thyroid diseases%Malondialdehyde
对初诊为自身免疫性甲状腺疾病甲状腺功能亢进症(甲亢)33例、亚临床甲亢21例、甲状腺功能减退症(甲减)25例、亚临床甲减23例、甲状腺功能正常15例,正常对照30例,进行血浆丙二醛(MDA)、超氧化物歧化酶(SOD)和炎症因子检测.甲状腺功能异常各组MDA水平显著高于正常对照组(P<0.01或P<0.05),SOD/MDA比值显著低于正常对照组(P<0.01或P<0.05);超敏C反应蛋白、肿瘤坏死因子是MDA重要影响因素.
對初診為自身免疫性甲狀腺疾病甲狀腺功能亢進癥(甲亢)33例、亞臨床甲亢21例、甲狀腺功能減退癥(甲減)25例、亞臨床甲減23例、甲狀腺功能正常15例,正常對照30例,進行血漿丙二醛(MDA)、超氧化物歧化酶(SOD)和炎癥因子檢測.甲狀腺功能異常各組MDA水平顯著高于正常對照組(P<0.01或P<0.05),SOD/MDA比值顯著低于正常對照組(P<0.01或P<0.05);超敏C反應蛋白、腫瘤壞死因子是MDA重要影響因素.
대초진위자신면역성갑상선질병갑상선공능항진증(갑항)33례、아림상갑항21례、갑상선공능감퇴증(갑감)25례、아림상갑감23례、갑상선공능정상15례,정상대조30례,진행혈장병이철(MDA)、초양화물기화매(SOD)화염증인자검측.갑상선공능이상각조MDA수평현저고우정상대조조(P<0.01혹P<0.05),SOD/MDA비치현저저우정상대조조(P<0.01혹P<0.05);초민C반응단백、종류배사인자시MDA중요영향인소.
One hundred and seventeen patients with newly diagnosed autoimmune thyroid diseases(AITDs)and 30 normal controls(NCs)were selected.All the patients were divided into 5 groups:hyperthyroidism group(n=33),subclinical hyperthyroidism group(n=21),hypothyroidism group(n=25),subclinical hypothyroidism group(n=23)and euthyroidism group(n=15).Plasma malondialdehyde(MDA),superoxide(SOD)and inflammatory factors levels were measured.Our results showed that plasma MDA level in dysthyroidism groups was significantly higher than that in NCs group(P<0.05 or P<0.01).SOD/MDA ratio in AITD groups Was significantly lower than that in NCs group(P<0.05 or P<0.01).In a multiple step-wise regression analysis,serum hishly sensitive C-reactive protein(hs-CRP)and tumor necrosis factor-α(TNF-α)were independent factors of MDA.This study might suggest that plasma MDA level in AITD patients receiving no treatment may increase.MDA may be correlated with hs-CRP or TNF-α levels.