CAJ | 학술논문

目的探讨地佐辛用于腹部肿瘤手术超前镇痛及术后静脉自控镇痛(PCIA)的有效性和安全性.方法选择60例剖腹行结肠癌根治术患者,年龄42 ～70岁,ASA Ⅰ～Ⅱ级,随机分为地佐辛组(D组)和舒芬太尼组(S组),各30例.所有患者选择全身麻醉,缝皮时静脉滴注地佐辛5 mg,手术结束时行PCIA,D组:地佐辛0.8 mg/kg,S组:舒芬太尼2μg/kg,均生理盐水稀释至100 ml.两组患者设置相同镇痛泵参数,监测并记录术后3、6、12、24、48 h VAS镇痛评分、48 h内按压镇痛泵次数、Ramsay镇静评分及不良反应发生情况.结果两组患者术后各时点VAS评分及48 h内按压镇痛泵次数比较差异无统计学意义(P＞0.05),D组患者的Ramsay评分及不良反应发生率均显著低于S组(P＜0.05).结论地佐辛用于腹部肿瘤手术超前镇痛,效果确切,用于PCIA不良反应发生率低,安全性高,是一种较理想的超前镇痛及PCIA药物.
목적 탐토지좌신용우복부종류수술초전진통급술후정맥자공진통(PCIA)적유효성화안전성.방법 선택60례부복행결장암근치술환자,년령42 ～70세,ASA Ⅰ～Ⅱ급,수궤분위지좌신조(D조)화서분태니조(S조),각30례.소유환자선택전신마취,봉피시정맥적주지좌신5 mg,수술결속시행PCIA,D조:지좌신0.8 mg/kg,S조:서분태니2μg/kg,균생리염수희석지100 ml.량조환자설치상동진통빙삼수,감측병기록술후3、6、12、24、48 h VAS진통평분、48 h내안압진통빙차수、Ramsay진정평분급불량반응발생정황.결과 량조환자술후각시점VAS평분급48 h내안압진통빙차수비교차이무통계학의의(P＞0.05),D조환자적Ramsay평분급불량반응발생솔균현저저우S조(P＜0.05).결론 지좌신용우복부종류수술초전진통,효과학절,용우PCIA불량반응발생솔저,안전성고,시일충교이상적초전진통급PCIA약물.
Objective To observe the effect of dezocine on preemptive analgesia and patient controlled intravenous analgesia following resection of abdominal tumor.Methods Sixty patients scheduled for resection of colon cancer,aged 42 ～ 70,ASA Ⅰ ～ Ⅱ,were randomly divided into two groups,dezocine group(group D)and sufentanil group(group S),with 30 patients in either group.All patients were given general anesthesia,intravenous injection of dezocine 5 mg when sewing skin and treated with patient controlled intravenous analgesia(PCIA)at the end of operation.PCIA gradients used for group D,group S were decozine 0.8 mg/kg and sufentanil 2 μg/kg respectively,which were diluted to 100 ml by adding saline.VAS,Ramsay scores(3 h,6 h,12 h,24 h,48 h after operation),pressing times of PCA equipment and adverse effects were recorded and compared.Results There were no significant differences in the VAS scores and pressing times of PCA equipment(P ＞ 0.05).The Ramsay scores and adverse effects of group D were significantly lower than the group S(P ＜ 0.05).Conclusions Dezocine on preemptive analgesia and patient controlled intravenous analgesia following resection of abdominal tumor exhibits good effect of and minor adverse reactions; which enables a safer and more effective method of analgesia.