CAJ | 학술논문

目的观察TAD方案(亚砷酸、维生素C、地塞米松)联合美法仑治疗多发性骨髓瘤(MM)的临床疗效.方法 18例MM患者,男12例,女6例.采用TAD方案加美法仑(亚砷酸10mg,第1天至第5天,第8天至第12天;维生素C 1.0 g,第l天至第5天,第8天至第12天;地塞米松20 mg,第1天至第4天,第8天至第11天;美法仑2 mg,3次/d,第1天至第12天)治疗初治及难治复发性MM,观察18例患者中完全缓解(CR)、部分反应(PR)、微小反应(MR)、无改变(NC)比例.结果 18例患者中CR 3例(16.7%),PR 14例(77.7%),MR 1例(5.6%).结论亚砷酸、美法仑、维生素C、地塞米松联合应用是一种有效且副作用小的治疗初治或难治性MM的方案.
목적 관찰TAD방안(아신산、유생소C、지새미송)연합미법륜치료다발성골수류(MM)적림상료효.방법 18례MM환자,남12례,녀6례.채용TAD방안가미법륜(아신산10mg,제1천지제5천,제8천지제12천;유생소C 1.0 g,제l천지제5천,제8천지제12천;지새미송20 mg,제1천지제4천,제8천지제11천;미법륜2 mg,3차/d,제1천지제12천)치료초치급난치복발성MM,관찰18례환자중완전완해(CR)、부분반응(PR)、미소반응(MR)、무개변(NC)비례.결과 18례환자중CR 3례(16.7%),PR 14례(77.7%),MR 1례(5.6%).결론 아신산、미법륜、유생소C、지새미송연합응용시일충유효차부작용소적치료초치혹난치성MM적방안.
Objective To observe the clinical results of combination therapy for multiple myeloma by arsenic trioxide,melphalan,vitamin C and dexamethasone.Methods 18 cases with multiple myeloma,12 males and 6 females were given the treatment including arsenic trioxide,melphalan,vitamin C and dexamethasone combination therapy;the dosage of arsenic trioxide 10 mg,d1～5,d8～12;vitamin C 1.0 g,d1～5,d8～12;dexamethasone 20 mg,d1～4,d8～11;melphalan 2 mg,tid,d1～12.Complete response(CR),partial response(PR),minimal response(MR),no ehange(NC)were observed.Results The CR werel6.7%(3/18),PR were 77.7%(14/t8),MR were 5.6%(1/18).Conclusion Combinational arsenic trioxide,melphalan,vitamin C and dexamethasone is an effective therapy with less side effects,which can be considered for treating the initial or relapsed or refractory MM.