中华急诊医学杂志
中華急診醫學雜誌
중화급진의학잡지
CHINESE JOURNAL OF EMERGENCY MEDICINE
2010年
3期
277-280
,共4页
陈亮%马中富%唐皓%梁艳冰%陈志斌%李振宇%黄子通%蒋龙元
陳亮%馬中富%唐皓%樑豔冰%陳誌斌%李振宇%黃子通%蔣龍元
진량%마중부%당호%량염빙%진지빈%리진우%황자통%장룡원
心源性猝死%心肌梗死%细胞因子信号转导抑制分子-1%细胞因子信号转导抑制分子-3
心源性猝死%心肌梗死%細胞因子信號轉導抑製分子-1%細胞因子信號轉導抑製分子-3
심원성졸사%심기경사%세포인자신호전도억제분자-1%세포인자신호전도억제분자-3
Sudden cardiac death%Myocardial infarction%Suppressor of eytokine signaling-1%Suppressor of cytokine signaling-3
目的 探讨心源性猝死(sudden cardiac death,SCD)患者心肌中细胞因子信号转导抑制分子-1(suppressor of cytokine signaling-1,SOCS-1)和SOCS-3的表达及临床意义.方法 取2005-2006年中山大学法医学系的尸检心肌标本24例,其中9例尸检符合冠状动脉粥样硬化(非心肌梗死)导致SCD(简称非心梗组),7例尸检符合急性心肌梗死猝死(简称心梗组),对照组8例选择了因交通事故、外伤等所致死亡的患者.以RT-PCR法检测对照组、非心梗组和心梗组心肌中SOCS-1,SOCS-3的mRNA表达,用免疫组化法检测对照组、非心梗组和心梗组心肌中SOCS-1,SOCS-3的蛋白表达.数据以SPSS13.0统计学软件处理,采用方差分析检验.结果 非心梗组和心梗组患者心肌中SOCS-1 mRNA,SOCS-3 mRNA的表达量均显著高于对照组,分别为[(0.788±0.101),(0.741±0.111)vs.(0.436±0.044),P<0.01],及[(0.841±0.092),(0.776±0.070)vs.(0.454±0.076),P<0.01].非心梗组和心梗组患者心肌中SOCS-1的蛋白抗体阳性细胞数均显著高于对照组,分别为[(320.00±48.48),(347.14±70.88)vs.(42.50±10.35),P<0.01].非心梗组和心梗组患者心肌中SOCS-3的蛋白抗体阳性细胞数均显著高于对照组,分别为[(381.11±59.25)vs.(40.00±10.69),P<0.01]和[(332.86±111.91)vs.(40.00±10.69),P<0.01].结论 冠心病所致SCD患者的心肌中SOCS-1,SOCS-3的表达显著增加,提示它们可能参与了SCD的发病机制.
目的 探討心源性猝死(sudden cardiac death,SCD)患者心肌中細胞因子信號轉導抑製分子-1(suppressor of cytokine signaling-1,SOCS-1)和SOCS-3的錶達及臨床意義.方法 取2005-2006年中山大學法醫學繫的尸檢心肌標本24例,其中9例尸檢符閤冠狀動脈粥樣硬化(非心肌梗死)導緻SCD(簡稱非心梗組),7例尸檢符閤急性心肌梗死猝死(簡稱心梗組),對照組8例選擇瞭因交通事故、外傷等所緻死亡的患者.以RT-PCR法檢測對照組、非心梗組和心梗組心肌中SOCS-1,SOCS-3的mRNA錶達,用免疫組化法檢測對照組、非心梗組和心梗組心肌中SOCS-1,SOCS-3的蛋白錶達.數據以SPSS13.0統計學軟件處理,採用方差分析檢驗.結果 非心梗組和心梗組患者心肌中SOCS-1 mRNA,SOCS-3 mRNA的錶達量均顯著高于對照組,分彆為[(0.788±0.101),(0.741±0.111)vs.(0.436±0.044),P<0.01],及[(0.841±0.092),(0.776±0.070)vs.(0.454±0.076),P<0.01].非心梗組和心梗組患者心肌中SOCS-1的蛋白抗體暘性細胞數均顯著高于對照組,分彆為[(320.00±48.48),(347.14±70.88)vs.(42.50±10.35),P<0.01].非心梗組和心梗組患者心肌中SOCS-3的蛋白抗體暘性細胞數均顯著高于對照組,分彆為[(381.11±59.25)vs.(40.00±10.69),P<0.01]和[(332.86±111.91)vs.(40.00±10.69),P<0.01].結論 冠心病所緻SCD患者的心肌中SOCS-1,SOCS-3的錶達顯著增加,提示它們可能參與瞭SCD的髮病機製.
목적 탐토심원성졸사(sudden cardiac death,SCD)환자심기중세포인자신호전도억제분자-1(suppressor of cytokine signaling-1,SOCS-1)화SOCS-3적표체급림상의의.방법 취2005-2006년중산대학법의학계적시검심기표본24례,기중9례시검부합관상동맥죽양경화(비심기경사)도치SCD(간칭비심경조),7례시검부합급성심기경사졸사(간칭심경조),대조조8례선택료인교통사고、외상등소치사망적환자.이RT-PCR법검측대조조、비심경조화심경조심기중SOCS-1,SOCS-3적mRNA표체,용면역조화법검측대조조、비심경조화심경조심기중SOCS-1,SOCS-3적단백표체.수거이SPSS13.0통계학연건처리,채용방차분석검험.결과 비심경조화심경조환자심기중SOCS-1 mRNA,SOCS-3 mRNA적표체량균현저고우대조조,분별위[(0.788±0.101),(0.741±0.111)vs.(0.436±0.044),P<0.01],급[(0.841±0.092),(0.776±0.070)vs.(0.454±0.076),P<0.01].비심경조화심경조환자심기중SOCS-1적단백항체양성세포수균현저고우대조조,분별위[(320.00±48.48),(347.14±70.88)vs.(42.50±10.35),P<0.01].비심경조화심경조환자심기중SOCS-3적단백항체양성세포수균현저고우대조조,분별위[(381.11±59.25)vs.(40.00±10.69),P<0.01]화[(332.86±111.91)vs.(40.00±10.69),P<0.01].결론 관심병소치SCD환자적심기중SOCS-1,SOCS-3적표체현저증가,제시타문가능삼여료SCD적발병궤제.
Objective To investigate the expressions and clinical significanees of suppressors of cytokine signaling-1 (SOCS-1) and SOCS-3 in myocardium of patients with sudden cardiac death (SCD). Method This study included myocardial autopsy specimens of 24 patients admitted between 2005 and 2006. Of them, 9 cases had the findings of autopsy examination consistent with coronary atberosclerosis (non-myocardial infarction) leading to SCD (non-MI group), 7 patients died of acute myocardial infarction (MI group) and 8 patients died of traffic accidents and trauma The expressions of SOCS-1 mRNA and SOCS-3 mRNA in the myocardium of non-MI and con-trol group were detected by using RT-PCR. The levels of SOCS-1 protein and SOCS-3 protein were detected by us-ing immunohistochemistry. Statistical analysis were performed by using SPSS version 13.0 software and the data were processed with ANOVA test. Results The expressions of SOCS-1 mRNA and SOCS-3 mRNA in non-MI and MI groups were were significantly higher than those in control group (0. 788±0. 101) and (0. 741±0.111) vs.(0.436±0.044) (P <0.01); (0.841±0.092) and (0.776±0.070) vs.(0.454±0.076), P <0.01, re-spectively). The antibody-positive cells of SOCS-1 protein in myocardium of non-MI group and MI group were significantly higher than those in myoeardium of control group (320.00±48.48) and (347.14±70.88) vs.(42.50±10.35) (P < 0.01), respectively. The antibody-positive cells of SOCS-3 protein in myoeardium of non-MI group and MI group were significantly higher than those in myocardium of control group (381.11±59.25) vs.(40.00±10.69), (P < 0.01)and (332.86±111.91) vs. (40.00±10.69), (P =0.001). Conclusions The expressions of SOCS rnRNA and SOCS-3 mRNA in myoeardium of patients with SCD from coronary diseases are significantly increased contributing to the pathogenesis of SCD.