CAJ | 학술논문

造血干细胞移植(HSCT)已广泛应用于临床,是治疗血液系统疾患、实体瘤、基因缺陷及自身免疫性疾病的重要手段.干细胞移植伴随着严重的免疫缺陷.这一时期,患者有合并严重感染的风险固有免疫恢复迅速,NK细胞、树突状细胞移植后数周内即可恢复.而适应性免疫系统恢复缓慢,T细胞和B细胞移植后数月才可恢复正常,而T细胞功能恢复需要数年的时间.研究造血系统各细胞在移植后数量、功能上的恢复规律,对如何加快免疫重建,降低移植死亡率有重要意义.
조혈간세포이식(HSCT)이엄범응용우림상,시치료혈액계통질환、실체류、기인결함급자신면역성질병적중요수단.간세포이식반수착엄중적면역결함.저일시기,환자유합병엄중감염적풍험고유면역회복신속,NK세포、수돌상세포이식후수주내즉가회복.이괄응성면역계통회복완만,T세포화B세포이식후수월재가회복정상,이T세포공능회복수요수년적시간.연구조혈계통각세포재이식후수량、공능상적회복규률,대여하가쾌면역중건,강저이식사망솔유중요의의.
Hematopoietic stem cell transplantation(HSCT)has been widely used in clinical practice. It has become an important treatment for hematological disorders,solid tumors,genetic defects and autoimmune diseases.HSCT is associated with severe immune deficiency.As a result,patients receiving HSCT are at hish risk of infections.Innate immunity.including NK cell and dendritic cells.recovers within weeks after transplantation.By contrast.adaptive immunity recovers much slower.B-and T-cell counts return to normal level during the first few months after transplantation.However,T-cell immunity may remain impaired for years.To study the quantitative and functional of recovery of cells in the hematopoietic system is vital important for the understanding of how to accelerate immune reomstitution and to reduce transplant mortality.