CAJ | 학술논문

浸润和转移是恶性肿瘤的重要特征,也给肿瘤的治疗带来困难,是预后不良的重要因素.转移抑制因子23(non-metastasis,NM23)基因是最早发现的抗肿瘤转移基因之一.现在已经发现NM23是一个基因家族,包括NM23-H1、NM23-H2等重要的基因家族成员.研究表明NM23基因表达与实体瘤转移抑制有关,在很多实体瘤中可以作为进展和预后的分子标记.随着对NM23基因调控肿瘤转移的分子机制的研究的进一步开展,已经发现了一些NM23肿瘤转移抑制通路上下游的相关调控分子,为进一步的信号通路研究创造了条件.本文概述了近年来对NM23基因转移抑制通路研究的新近展,提出了以后可能的研究方向和需要解决的关键问题.
침윤화전이시악성종류적중요특정,야급종류적치료대래곤난,시예후불량적중요인소.전이억제인자23(non-metastasis,NM23)기인시최조발현적항종류전이기인지일.현재이경발현NM23시일개기인가족,포괄NM23-H1、NM23-H2등중요적기인가족성원.연구표명NM23기인표체여실체류전이억제유관,재흔다실체류중가이작위진전화예후적분자표기.수착대NM23기인조공종류전이적분자궤제적연구적진일보개전,이경발현료일사NM23종류전이억제통로상하유적상관조공분자,위진일보적신호통로연구창조료조건.본문개술료근년래대NM23기인전이억제통로연구적신근전,제출료이후가능적연구방향화수요해결적관건문제.
Invasion and metastasis are two important features in malignant tumor, which bring greattrouble to cancer treatment, and are important impact factors for bad prognosis. NM23 gene has been reportedas one of the earliest tumor metastasis suppressive genes for a few years. Presently it reveals that NM23 is agene family including NM23-H1 and NM23-H2, two most important family members. It suggests the expressionof NM23 gene is associated with metastasis suppression and can be taken as molecular marker for advance orprognosis of many substantial tumors. With the development of studies on molecular mechanism of tumor metas-tasis regulation for NM23 gene, several control components with regulating role have been found, which providea basis for further research on NM23 gene pathway. This review summarizes the new advancement on NM23pathway in recent years and puts forward possible directions for further researches and key problems to besolved.