CAJ | 학술논문

目的探讨不同亚型肾癌组织中c-kit及增殖细胞核抗原(PCNA)的表达及临床意义.方法采用免疫组化SP法测定137例透明细胞癌、82例乳头状癌、51例嫌色细胞癌标本中c-kit蛋白和PCNA的表达情况. 结果嫌色细胞癌中c-kit强阳性表达率为94.1%(48/51),明显高于透明细胞癌的16.1%(22/137)及乳头状癌的28.1%(23/82),差异有统计学意义(P=0.001).c-kit强阳性表达仅与嫌色细胞癌分期有关(P=0.038);在透明细胞癌和乳头状癌中PCNA表达与分级关系密切(P=0.043,P=0.011),而与嫌色细胞癌分级无关. 结论嫌色细胞癌中c-kit表达率明显高于其他肾癌亚型,且与肿瘤局部进展关系密切.不同亚型间c-kit表达差异有助于肾癌的临床鉴别诊断和指导晚期肾癌靶向治疗药物的选择.
목적 탐토불동아형신암조직중c-kit급증식세포핵항원(PCNA)적표체급림상의의.방법 채용면역조화SP법측정137례투명세포암、82례유두상암、51례혐색세포암표본중c-kit단백화PCNA적표체정황. 결과 혐색세포암중c-kit강양성표체솔위94.1%(48/51),명현고우투명세포암적16.1%(22/137)급유두상암적28.1%(23/82),차이유통계학의의(P=0.001).c-kit강양성표체부여혐색세포암분기유관(P=0.038);재투명세포암화유두상암중PCNA표체여분급관계밀절(P=0.043,P=0.011),이여혐색세포암분급무관. 결론 혐색세포암중c-kit표체솔명현고우기타신암아형,차여종류국부진전관계밀절.불동아형간c-kit표체차이유조우신암적림상감별진단화지도만기신암파향치료약물적선택.
Objective To investigate the expression of c-kit and analyze its relationship with proliferating cell nuclear antigen (PCNA) in RCC subtypes and its clinical progression. Methods Expression of c-kit protein was retrospectively studied with immunohistochemistry in paraffin sections from 137 cases of clear renal cell carcinoma (CCRCC), 82 papillary renal cell carcinoma (PRCC), 51 chromophobe renal cell carcinoma (ChRCC). Results The positive rate of c-kit in ChRCC was 94.1%(48/51), it was statistically higher than that in CCRCC (16. 1%, 22/137) and PRCC (28.1 %, 23/82)(P=0. 001 ). In ChRCC, the positive expression of c-kit was related with TNM stages. The positive expression of PCNA was related with the grade in CCRCC and PRCC. But there was no relationship between PCNA expression and grade of ChRCC. It also had the relationship with the metastasis in CCRCC. Conclusions The expression of c-kit in ChRCC is higher than in other subtype of RCC, and associated with tumor local progression. That makes c-kit as a helpful marker to discriminate different subtypes of kidney cancer.