中华医学杂志
中華醫學雜誌
중화의학잡지
National Medical Journal of China
2011年
16期
1088-1091
,共4页
叶建红%舒晓春%陈苹%麦伟华%郎江明
葉建紅%舒曉春%陳蘋%麥偉華%郎江明
협건홍%서효춘%진평%맥위화%랑강명
代谢综合征X%脂联素%瘦素%葡萄糖代谢率
代謝綜閤徵X%脂聯素%瘦素%葡萄糖代謝率
대사종합정X%지련소%수소%포도당대사솔
Metabolic syndrome X%Adiponectin%Leptin%Glucose metabolic rate
目的 探讨代谢综合征(MS)患者葡萄糖代谢率与血浆脂联素、瘦素水平的关系.方法 筛选30例MS患者和20名健康者为对照组.所有受试者均行高胰岛素-正常血糖钳夹试验;检测血浆脂联素与瘦素浓度及空腹胰岛素(FTNS)、血糖、血脂等生化指标;测定血压、腰围、身高、体重等人体参数.结果 (1)高胰岛素-正常血糖钳夹试验稳态时(120～150 min),MS组的葡萄糖代谢率显著低于对照组[(8.33±1.59)与(4.13±1.34)mg·kg-1·min-1],差异有统计学意义(P＜0.01).(2)MS组的血浆脂联素水平显著低于对照组[(5.15±2.54)mg/L比(10.28±5.50)mg/L,P＜0.01],瘦素水平显著高于对照组[(189±90)μg/L比(127±73)μg/L,P＜0.01].(3)在MS组,腰围、体质指数、甘油三酯、高密度脂蛋白胆固醇、FINS、脂联素、瘦素等与葡萄糖代谢率相关(均P＜0.05).结论 提示MS患者的胰岛素抵抗可能与血浆脂联素降低及瘦素升高有关.
目的 探討代謝綜閤徵(MS)患者葡萄糖代謝率與血漿脂聯素、瘦素水平的關繫.方法 篩選30例MS患者和20名健康者為對照組.所有受試者均行高胰島素-正常血糖鉗夾試驗;檢測血漿脂聯素與瘦素濃度及空腹胰島素(FTNS)、血糖、血脂等生化指標;測定血壓、腰圍、身高、體重等人體參數.結果 (1)高胰島素-正常血糖鉗夾試驗穩態時(120～150 min),MS組的葡萄糖代謝率顯著低于對照組[(8.33±1.59)與(4.13±1.34)mg·kg-1·min-1],差異有統計學意義(P＜0.01).(2)MS組的血漿脂聯素水平顯著低于對照組[(5.15±2.54)mg/L比(10.28±5.50)mg/L,P＜0.01],瘦素水平顯著高于對照組[(189±90)μg/L比(127±73)μg/L,P＜0.01].(3)在MS組,腰圍、體質指數、甘油三酯、高密度脂蛋白膽固醇、FINS、脂聯素、瘦素等與葡萄糖代謝率相關(均P＜0.05).結論 提示MS患者的胰島素牴抗可能與血漿脂聯素降低及瘦素升高有關.
목적 탐토대사종합정(MS)환자포도당대사솔여혈장지련소、수소수평적관계.방법 사선30례MS환자화20명건강자위대조조.소유수시자균행고이도소-정상혈당겸협시험;검측혈장지련소여수소농도급공복이도소(FTNS)、혈당、혈지등생화지표;측정혈압、요위、신고、체중등인체삼수.결과 (1)고이도소-정상혈당겸협시험은태시(120～150 min),MS조적포도당대사솔현저저우대조조[(8.33±1.59)여(4.13±1.34)mg·kg-1·min-1],차이유통계학의의(P＜0.01).(2)MS조적혈장지련소수평현저저우대조조[(5.15±2.54)mg/L비(10.28±5.50)mg/L,P＜0.01],수소수평현저고우대조조[(189±90)μg/L비(127±73)μg/L,P＜0.01].(3)재MS조,요위、체질지수、감유삼지、고밀도지단백담고순、FINS、지련소、수소등여포도당대사솔상관(균P＜0.05).결론 제시MS환자적이도소저항가능여혈장지련소강저급수소승고유관.
Objective To investigate the relationship of glucose metabolic rate (GMR) and plasma levels of adiponectin and leptin in patients with metabolic syndrome (MS). Methods A total of 30 MS subjects aged 36 -60 years old were selected as MS group. And 20 normal adults were selected as control group. The GMR was evaluated by the technique of hyperinsulinemic euglycemia clamp. The plasma concentrations of adiponectin and leptin were detected by enzyme-linked immunosorbent assay (ELISA). Blood pressure, waist circumference (WC), body weight and body height were measured.Results ( 1 ) During the steady state ( last 30 min), the GMR was significantly lower in MS group than that in control Group [ (4. 13 ± 1.34) mg· kg- 1 · min -1 vs ( 8.33 ± 1.59 ) mg · kg- 1 · min -1, P ＜ 0. 01 ].(2) The plasma level of adiponectin was significantly lower in MS group than that in control group [ (5. 15 ±2. 54) μg/ml vs ( 10. 28 ±5.50 ) μg/ml, P ＜0. 01 ]. The plasma level of leptin were significantly higher in MS group than that in control group [(189.37 ±90.48) nng/ml vs(126.55 ±72.70) ng/ml, P ＜0.01].(3) In MS group, glucose metabolic rate was associated with WC, BMI, TG, HDL-C FINS, leptin, and adiponectin, ( all P ＜ 0. 05 ). Conclusion The technique of hyperinsulinemic euglycemic clamp shows that the BMR of MS patients significantly decreases. It may be associated with their lowered plasma levels of adiponectin and leptin.
