CAJ | 학술논문

目的：探讨我国北方地区乳腺癌病人的5年生存率、主要预后因素及其与加拿大类似气候地区的异同。方法：收集吉林大学第一医院(中国长春，简称FTH)和拉瓦尔大学圣萨可门医院(加拿大魁北克，简称SSH)1 002例乳腺癌病人的资料，包括自然状况及预后因素(经历史性队列研究)，采用Kaplan-Meier方法计算生存指标，并进行分层比较。结果：病人的平均年龄FTH较SSH小10岁(P<0.000 1)；病人原发肿瘤大小差异有显著性(P=0.036)；腋窝淋巴结有转移病人的比例FTH明显地高于SSH(P<0.000 1) ；手术方式FTH多为乳腺癌改良根治术，SSH则对Ⅰ、Ⅱ期病人首选局部切除；病人术后5年生存率：FTH为74.2%，SSH为76.3%，差异不显著(P=0.302)。结论：尽管两所医院病人的就诊年龄、肿瘤大小、淋巴结转移个数有不同，但其5年生存率却无显著性差异。
목적：탐토아국북방지구유선암병인적5년생존솔、주요예후인소급기여가나대유사기후지 구적이동。방법：수집길림대학제일의원(중국장춘，간칭FTH)화랍와이대학골살가문의 원(가나대괴북극，간칭SSH)1 002례유선암병인적자료，포괄자연상황급예후인소(경역사 성대렬연구)，채용Kaplan-Meier방법계산생존지표，병진행분층비교。결과：병인적평균년령FTH교SSH소10세(P<0.000 1)；병인원발종류대소차이유 현저성(P=0.036)；액와림파결유전이병인적비례FTH명현지고우SSH(P<0.000 1) ；수술방식FTH다위유선암개량근치술，SSH칙대Ⅰ、Ⅱ기병인수선국부절제；병인술후5년 생존솔：FTH위74.2%，SSH위76.3%，차이불현저(P=0.302)。 결론：진관량소의원병인적취진년령、종류대소、림파결전이개수유불동，단기5년생존솔 각무현저성차이。
Objective:To explore th five year survivals and some prognostic factors for bres at cancer patients in the north areas of China,and the indentification or differ e nces on these variables among breast cancer patients between in China and in Can ada.Methods:All Data were collected from the hospital records of 1 002 breast cancer patients who were initially treated at the First Hospital of Jilin Uni versity (116 cases FTH,Changchun China) and the Sain t-Sacrement Hospital (886 cases in SSH,Quebec Canada) respectively by use of Historical Cohort survey,and the survival propotions were calculated and comp ared stradly by use of Kaplan-Meier method.Results:Age at diagnosis was substantially lower (average of age about 10 years less) among breast cancer patients seen at FTH compared to those treated at SSH (P<0.0001).Patients in the two hospitals differed in respect to tumor size at pathology (P=0.036).The proportion of women with lymph node involvement was greater at FTH (61.1%) than that at HSS(37.3%)(P<0.0001).Surgical treat ment of breats cancer was varied considerably:the radical mastectomy was frequen tly performed for andy stage of breast cancer patients in Changchun,but the part ial mastectomy was mainly used for patients with stage Ⅰ or Ⅱ in Quebec.The fi ve year survival was 74.2% among breast cacer patients seen at FTH compared to 7 6.3% among women treated at HSS,and there was no singnificant differrence (P =0.302). Conclusion:Five year survival of breast cancer patients treated surgically in C hangchun,China,was similar to that of patients treated surgically in Quebec,Can ada except for differences in age at diagnosis,tumor size and lymph node involve ment