中国全科医学
中國全科醫學
중국전과의학
CHINESE GENERAL PRACTICE
2010年
3期
288-290
,共3页
糖尿病%2型%胰岛素输注系统%诺和锐%继发性磺脲类药物失效%治疗结果
糖尿病%2型%胰島素輸註繫統%諾和銳%繼髮性磺脲類藥物失效%治療結果
당뇨병%2형%이도소수주계통%낙화예%계발성광뇨류약물실효%치료결과
Diabetes mellitus,type 2%Insulin infusion systems%Aspart%Secondary sulfonylureas failure%Treatment outcome
目的 观察胰岛素泵持续皮下输注诺和锐强化治疗2型糖尿病并继发性磺脲类药物失效的疗效.方法 选择100例2型糖尿病并继发性磺脲类药物失效患者,将其随机分为胰岛素泵持续皮下输注(CSII)诺和锐组(CSII组)和每日常规2次胰岛素皮下注射组(MSII组),各50例.两组患者均给予糖尿病教育、饮食控制及适量运动.MSII组患者每天早晚餐前30 min皮下注射诺和灵30R,共治疗4周;CSII组给予CSII治疗,输注的胰岛素为诺和锐.比较治疗前后两组患者的血糖(三餐前、三餐后2 h、睡前、凌晨2:00血糖)、胰岛素用量、血糖达标时间、住院时间及低血糖发生率.结果 治疗后CSII组患者三餐后2 h血糖、胰岛素用量、血糖达标时间及住院时间分别为(7.8±1.2)mmol/L、(0.58±0.14)U·kg~(-1)·d~(-1)、(3.2±1.9)d和(10.4±2.6)d,MSII组分别为(9.0±1.4)mmol/L、(0.74±0.17)U·kg~(-1)·d~(-1)、(7.7±2.9)d和(12.9±3.5)d,差异均有统计学意义(P＜0.01).治疗中CSII组无低血糖发生,MSII组有4例发生低血糖.结论 胰岛素泵持续输注诺和锐强化治疗2型糖尿病并继发性磺脲类药物失效的临床疗效显著优于MSII.
目的 觀察胰島素泵持續皮下輸註諾和銳彊化治療2型糖尿病併繼髮性磺脲類藥物失效的療效.方法 選擇100例2型糖尿病併繼髮性磺脲類藥物失效患者,將其隨機分為胰島素泵持續皮下輸註(CSII)諾和銳組(CSII組)和每日常規2次胰島素皮下註射組(MSII組),各50例.兩組患者均給予糖尿病教育、飲食控製及適量運動.MSII組患者每天早晚餐前30 min皮下註射諾和靈30R,共治療4週;CSII組給予CSII治療,輸註的胰島素為諾和銳.比較治療前後兩組患者的血糖(三餐前、三餐後2 h、睡前、凌晨2:00血糖)、胰島素用量、血糖達標時間、住院時間及低血糖髮生率.結果 治療後CSII組患者三餐後2 h血糖、胰島素用量、血糖達標時間及住院時間分彆為(7.8±1.2)mmol/L、(0.58±0.14)U·kg~(-1)·d~(-1)、(3.2±1.9)d和(10.4±2.6)d,MSII組分彆為(9.0±1.4)mmol/L、(0.74±0.17)U·kg~(-1)·d~(-1)、(7.7±2.9)d和(12.9±3.5)d,差異均有統計學意義(P＜0.01).治療中CSII組無低血糖髮生,MSII組有4例髮生低血糖.結論 胰島素泵持續輸註諾和銳彊化治療2型糖尿病併繼髮性磺脲類藥物失效的臨床療效顯著優于MSII.
목적 관찰이도소빙지속피하수주낙화예강화치료2형당뇨병병계발성광뇨류약물실효적료효.방법 선택100례2형당뇨병병계발성광뇨류약물실효환자,장기수궤분위이도소빙지속피하수주(CSII)낙화예조(CSII조)화매일상규2차이도소피하주사조(MSII조),각50례.량조환자균급여당뇨병교육、음식공제급괄량운동.MSII조환자매천조만찬전30 min피하주사낙화령30R,공치료4주;CSII조급여CSII치료,수주적이도소위낙화예.비교치료전후량조환자적혈당(삼찬전、삼찬후2 h、수전、릉신2:00혈당)、이도소용량、혈당체표시간、주원시간급저혈당발생솔.결과 치료후CSII조환자삼찬후2 h혈당、이도소용량、혈당체표시간급주원시간분별위(7.8±1.2)mmol/L、(0.58±0.14)U·kg~(-1)·d~(-1)、(3.2±1.9)d화(10.4±2.6)d,MSII조분별위(9.0±1.4)mmol/L、(0.74±0.17)U·kg~(-1)·d~(-1)、(7.7±2.9)d화(12.9±3.5)d,차이균유통계학의의(P＜0.01).치료중CSII조무저혈당발생,MSII조유4례발생저혈당.결론 이도소빙지속수주낙화예강화치료2형당뇨병병계발성광뇨류약물실효적림상료효현저우우MSII.
Objective To explore the effect of insulin pomp continuous subcutaneous insulin infusion (CSII) on T2DM complicated by secondary sulfonylureas failure.Methods One hundred T2DM patients complicated by secondary sulfonylureas failure were divided randomly into groups CSII (receiving CSII)and MSII (receiving conventional insulin subcutaneous injection,twice/d),50 in each.Both were given diabetes education,diet control and regular exercises.MSII group were injected with 30 R novolin 30 min before breakfast,supper every day,4 weeks,and CSII group given CSII treatment (novorapid).The blood sugar (before meals,2 h after meals,before retiring,2:00 am blood sugar),insulin dosage,duration of normal glucose,length of hospital stay and incidence of low blood sugar were compared between 2 groups before treatment and after.Results After treatment,2 h postprandial glucose,insulin dosage,duration of normal glucose,length of hospital stay were 7.8±1.2mmol/L,0.58±0.14 U·kg~(-1)·d~(-1),3.2±1.9 d,10.4±2.6 d,respectively,in CSII group,and 9.0±1.4 mmol/L,0.74±0.17 U·kg~(-1)·d~(-1),7.7±2.9 d,12.9±3.5 d,respectively,in MSII group,the difference was significant (P＜0.05).There was no hypoglycemia occurring in CSII group,but there were 4 in MSII group.Conclusion The effect of insulin pump CSII is remarkably superior to that of MSII in intensive treatment of T2DM complicated by secondary sulfonylureas failure.
