CAJ | 학술논문

目的观察清肝利湿、健脾益肾法治疗中老年女性慢性尿路感染的临床疗效.方法按随机数字表法将82例中老年女性慢性尿路感染患者随机分为两组,治疗组42例采用清肝利湿、健脾益肾中药治疗;对照组40例给予敏感抗生素治疗,观察两组患者治疗后的临床疗效、安全性、免疫功能指标等方面的变化.结果治疗组临床近期治愈率为76.2％,总有效率为90.5％,完全治愈率为61.9％;对照组近期治愈率为50％,总有效率为65％,完全治愈率为27.5％.两组总有效率比较,差异有统计学意义(Z=2.740,P＜ 0.05).治疗组IgA、IgG、IgM水平提高;两组治疗后比较,差异有统计学意义(t值分别为9.1、10.5、11.2,P均＜0.01).治疗组CD4+上升、CD8+下降,CD4+/CD8+比值升高,与治疗前比较,差异有统计学意义(t值分别为13.3、8.6,P均＜0.01);对照组CD4+、CD8+及CD4+/CD8+水平变化不明显(P＞0.05).结论清肝利湿、健脾益肾法治疗中老年女性慢性尿路感染安全有效.
목적 관찰청간리습、건비익신법치료중노년녀성만성뇨로감염적림상료효.방법 안수궤수자표법장82례중노년녀성만성뇨로감염환자수궤분위량조,치료조42례채용청간리습、건비익신중약치료;대조조40례급여민감항생소치료,관찰량조환자치료후적림상료효、안전성、면역공능지표등방면적변화.결과 치료조림상근기치유솔위76.2％,총유효솔위90.5％,완전치유솔위61.9％;대조조근기치유솔위50％,총유효솔위65％,완전치유솔위27.5％.량조총유효솔비교,차이유통계학의의(Z=2.740,P＜ 0.05).치료조IgA、IgG、IgM수평제고;량조치료후비교,차이유통계학의의(t치분별위9.1、10.5、11.2,P균＜0.01).치료조CD4+상승、CD8+하강,CD4+/CD8+비치승고,여치료전비교,차이유통계학의의(t치분별위13.3、8.6,P균＜0.01);대조조CD4+、CD8+급CD4+/CD8+수평변화불명현(P＞0.05).결론 청간리습、건비익신법치료중노년녀성만성뇨로감염안전유효.
Objective To observe the clinical effect of the treatment of clearing liver fire,removing dampness,strengthening spleen and tonifying kidney in treating middle-aged and old woman with chronic urinary tract infection.Methods 82 cases were randomly divided into two groups.42 cases in treatment group were treated with herbal prescription of clearing liver fire,removing dampness,strengthening spleen and tonifying kidney,and 40 cases in control group were treated with sensitive antibiotics.The clinical effect,safety and changes of immune index were compared between two groups.Results In the treatment group,the recent cure rate was 76.8％,the total effective rate was 90.5％ and the complete cure rate was 61.9％; while in the control group,the recent cute rate was 50％,the total effective rate 65％ and the complete cure rate 27.5％.It showed significant difference between two groups (Z=2.740,P＜0.05).There was no significant difference between two groups in hepatic and renal function,serum and urine β2-MG level before and after treatment and it showed a better clinical safety in treatment group.The level of IgA,IgG and IgM increased after the treatment in treatment group.Comparing with the control group,the results showed significant differences(t=9.1,10.5 and 11.2 respectively,P＜0.01).In treatment group the level of CD4+was increased,CD8+was decreased,and the ratio of CD4+/CD8+ was increased obviously after the treatment.The differences before and after the treatment and between groups were significant(t=13.3,8.6,P＜0.01).In control group the level of CD4+、CD8+、CD4+/CD8 +did not change significantly.The differences before and after the treatment had no statistical significance (P＞0.05).Conclusion The treatment with herbs of clearing liver fire,removing dampness,strengthening slpeen and tonifying kidney had better effect,less side effect and good research prospect.