中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2012年
7期
991-992
,共2页
哮喘%T淋巴细胞%C反应蛋白质%降钙素%老年人
哮喘%T淋巴細胞%C反應蛋白質%降鈣素%老年人
효천%T림파세포%C반응단백질%강개소%노년인
Asthma%T-Lymphocytes%C-Reactive protein%Calcitonin%Aged
目的 了解外周血T淋巴细胞亚群、血清C反应蛋(CRP)、降钙素原(PCT)水平测定对老年哮喘患者的诊疗价值.方法 比较45例老年哮喘和50例中青年哮喘患者外周血T淋巴细胞水平的差异,及老年哮喘患者治疗前后血清CRP、PCT水平变化.结果 老年哮喘组CD3+、CD4+、CD8+、CD19+、NK细胞分别为(50.2±2.3)％、(41.5±1.3)％、(19.1±0.5)％、(21.8±1.9)％、(12.9±0.7)％,均低于对照组(均P＜0.05),而CD4+/CD8+为(2.6±0.9),高于对照组(P＜0.01).老年哮喘组治疗后CRP、PCT水平显著低于治疗前(P＜0.01).结论 老年哮喘的细胞免疫与体液免疫均下降,其急性发作或加重多与感染有关,CRP及PCT检测可判断感染,CRP是反应感染的敏感指标,PCT还可作为预后指标.
目的 瞭解外週血T淋巴細胞亞群、血清C反應蛋(CRP)、降鈣素原(PCT)水平測定對老年哮喘患者的診療價值.方法 比較45例老年哮喘和50例中青年哮喘患者外週血T淋巴細胞水平的差異,及老年哮喘患者治療前後血清CRP、PCT水平變化.結果 老年哮喘組CD3+、CD4+、CD8+、CD19+、NK細胞分彆為(50.2±2.3)％、(41.5±1.3)％、(19.1±0.5)％、(21.8±1.9)％、(12.9±0.7)％,均低于對照組(均P＜0.05),而CD4+/CD8+為(2.6±0.9),高于對照組(P＜0.01).老年哮喘組治療後CRP、PCT水平顯著低于治療前(P＜0.01).結論 老年哮喘的細胞免疫與體液免疫均下降,其急性髮作或加重多與感染有關,CRP及PCT檢測可判斷感染,CRP是反應感染的敏感指標,PCT還可作為預後指標.
목적 료해외주혈T림파세포아군、혈청C반응단(CRP)、강개소원(PCT)수평측정대노년효천환자적진료개치.방법 비교45례노년효천화50례중청년효천환자외주혈T림파세포수평적차이,급노년효천환자치료전후혈청CRP、PCT수평변화.결과 노년효천조CD3+、CD4+、CD8+、CD19+、NK세포분별위(50.2±2.3)％、(41.5±1.3)％、(19.1±0.5)％、(21.8±1.9)％、(12.9±0.7)％,균저우대조조(균P＜0.05),이CD4+/CD8+위(2.6±0.9),고우대조조(P＜0.01).노년효천조치료후CRP、PCT수평현저저우치료전(P＜0.01).결론 노년효천적세포면역여체액면역균하강,기급성발작혹가중다여감염유관,CRP급PCT검측가판단감염,CRP시반응감염적민감지표,PCT환가작위예후지표.
Objective To investigate the clinical value of peripheral blood T lymphocyte subset and serum C-reactive protein(CRP) and procalciton(PCT) for diagnosis and therapy in elderly asthma patients.Methods The difference of T lymphocyte subset was compared between 45 elderly asthma patients and 50 young and middle-aged asthma patients.The changes of CRP and PCT levels before and after therapy were compared in 45 patients with elderly asthma.Results The expression of CD3+,CD4+,CD8+,CD19+ and natural killer(NK) cell in elder patients were lower than the control group( all P ＜ 0.05 ),while CD4/CD8+ was higher( P ＜ 0.01 ).The levels of CRP and PCT were significantly lower after therapy than that before therapy (P ＜ 0.01 ).Conclusion The cytoimmunity and humoral immune function of elderly was decreased.The acute attack or exacerbation of asthma was related with infection.The detection of CRP and PCT could determine infection.CRP should be an sensitive marker to reflect infection,while PCTwas also a prognostic indicator.
