CAJ | 학술논문

目的:了解多焦视网膜电图(mfERG)在糖尿病患者早期视功能的变化规律.方法:将所有被检者分为正常对照组(33例)、糖尿病无视网膜病变组(63例)以及单纯期糖尿病视网膜病变组(43例).采用mfERG对上述3组进行检测,比较3组mfERG一阶反应N1波与P1波的潜伏期与反应密度.结果:在糖尿病无视网膜病变组中,N1波与P1波反应密度低于正常对照组,异常范围位于环1-环3.其中P1波反应密度在单纯期糖尿病视网膜病变组中进一步降低.N1波与P1波的潜伏期在糖尿病无视网膜病变组中的变化无统计学意义,在糖尿病视网膜病变组中延长,异常范围扩大到环4与环5.结论:mfERG在糖尿病视网膜病变出现之前已发生异常变化,且能够定量地反映随着病情的进展,视功能的损害程度及范围.
목적:료해다초시망막전도(mfERG)재당뇨병환자조기시공능적변화규률.방법:장소유피검자분위정상대조조(33례)、당뇨병무시망막병변조(63례)이급단순기당뇨병시망막병변조(43례).채용mfERG대상술3조진행검측,비교3조mfERG일계반응N1파여P1파적잠복기여반응밀도.결과:재당뇨병무시망막병변조중,N1파여P1파반응밀도저우정상대조조,이상범위위우배1-배3.기중P1파반응밀도재단순기당뇨병시망막병변조중진일보강저.N1파여P1파적잠복기재당뇨병무시망막병변조중적변화무통계학의의,재당뇨병시망막병변조중연장,이상범위확대도배4여배5.결론:mfERG재당뇨병시망막병변출현지전이발생이상변화,차능구정량지반영수착병정적진전,시공능적손해정도급범위.
AIM: To investigate the early changes of retinal function in diabetic patients detected by multifocal electroretinogram (mfERG).METHODS: The first-order kernel responses of mfERG were recorded from eyes of 33 normal control subjects,63 diabetic patients without retinopathy and 43 diabetic patients with background retinopathy. The response densities and implicit times of N1 and P1 were compared among the control, diabetic patients without retinopathy and diabetic patients with retinopathy.RESULTS: The response densities of N1 and P1 in central 3 rings were reduced significantly in diabetic eyes with and without retinopathy. And the implicit times of N1 and P1 were delayed significantly only in diabetic eyes with retinopathy.CONCLUSION: mfERG can detect the early changes of retinal function quantitatively in diabetic patients. Analysis of response densities and implicit times of N1 and P1 can reflect the progress of local retinal dysfunction in diabetes.