CAJ | 학술논문

烯醇酶不仅是糖酵解的关键酶,还具有其他多种功能,不仅存在于细胞质中,还在细胞膜、细胞核中存在.它在真核细胞和原核细胞表面具有纤溶酶原受体的功能.参与病原体与宿主纤溶酶原的结合,与病原体对宿主的侵袭和感染有关,是一个潜在的保护性抗原;它在细胞核内参与了基因转录的凋榨过程,具备热激蛋白(heat shock protein)的功能.该文着重对烯醇酶在寄生虫感染宿主、寄生虫与宿主相互作用的研究进展作简要综述,介绍烯醇酶在一系列生物学和疾病过程中结构与功能的相互关系.
희순매불부시당효해적관건매,환구유기타다충공능,불부존재우세포질중,환재세포막、세포핵중존재.타재진핵세포화원핵세포표면구유섬용매원수체적공능.삼여병원체여숙주섬용매원적결합,여병원체대숙주적침습화감염유관,시일개잠재적보호성항원;타재세포핵내삼여료기인전록적조자과정,구비열격단백(heat shock protein)적공능.해문착중대희순매재기생충감염숙주、기생충여숙주상호작용적연구진전작간요종술,개소희순매재일계렬생물학화질병과정중결구여공능적상호관계.
The enolase,not only is a key enzyme of glycolysis,but also has a variety of functions,existing in the cytoplasm,cell membrane as well as the nucleus.It acts as receptors for the host plasminogen existing in eukaryotic and prokaryotic cell surface,involved in the invasion and infection of pathogens to hosts,so it is a potential protective antigen.In nuclei it is involved in the regulation of gene transcription process,functioning as heat shock protein.This review focused on the research progress on the role of enolase in parasite infection,interaction between parasite and host,and introduced the mutual relations between the structure and the function of enolase in a series of biology and disease process.