中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2010年
24期
3329-3331
,共3页
周晓梅%周燕妮%张晓燕%曹湘竹
週曉梅%週燕妮%張曉燕%曹湘竹
주효매%주연니%장효연%조상죽
卵泡期%他莫昔芬%氯米芬抵抗%排卵率%妊娠率
卵泡期%他莫昔芬%氯米芬牴抗%排卵率%妊娠率
란포기%타막석분%록미분저항%배란솔%임신솔
Follicular phase%Tamoxifen%Clomiphene-resistant%Ovulation rate%Pregnancy rate
目的 探讨氯米芬(CC)联合他莫昔芬(tamoxifen)对CC抵抗的多囊卵巢综合征(PCOS)患者的促排卵效果.方法 将100例CC抵抗患者随机分为治疗组(A组)和对照组(B组).A组患者在月经第3～7天口服CG 100 mg/d,同时在月经周期的第3～7天口服他莫昔芬40 mg/d;B组CC的应用同A组.月经第8 d开始监测卵泡发育情况.当有1个卵泡直径≥18 rmm或2个卵泡直径≥17 mm时,肌注hCG1 0 000 IU,36 h后性生活.观察两组注射hCG日成熟卵泡数和子宫内膜厚度、促排卵天数、月经周期第22天孕酮水平、排卵率和妊娠率.结果 A组注射hCG日的成熟卵泡数、子宫内膜厚度、月经第21 d血清中孕酮水平以及排卵率和妊娠率与B组相比差异均有统计学意义(P＜0.05～P＜0.01);促排卵天数组间无统计学意义(P＞0.05).结论 对CC抵抗的PCOS患者,他莫昔芬可以促进排卵,改善CC对子宫内膜的抗雌激素效应,增加子宫内膜厚度,提高排卵率和妊娠率.
目的 探討氯米芬(CC)聯閤他莫昔芬(tamoxifen)對CC牴抗的多囊卵巢綜閤徵(PCOS)患者的促排卵效果.方法 將100例CC牴抗患者隨機分為治療組(A組)和對照組(B組).A組患者在月經第3～7天口服CG 100 mg/d,同時在月經週期的第3～7天口服他莫昔芬40 mg/d;B組CC的應用同A組.月經第8 d開始鑑測卵泡髮育情況.噹有1箇卵泡直徑≥18 rmm或2箇卵泡直徑≥17 mm時,肌註hCG1 0 000 IU,36 h後性生活.觀察兩組註射hCG日成熟卵泡數和子宮內膜厚度、促排卵天數、月經週期第22天孕酮水平、排卵率和妊娠率.結果 A組註射hCG日的成熟卵泡數、子宮內膜厚度、月經第21 d血清中孕酮水平以及排卵率和妊娠率與B組相比差異均有統計學意義(P＜0.05～P＜0.01);促排卵天數組間無統計學意義(P＞0.05).結論 對CC牴抗的PCOS患者,他莫昔芬可以促進排卵,改善CC對子宮內膜的抗雌激素效應,增加子宮內膜厚度,提高排卵率和妊娠率.
목적 탐토록미분(CC)연합타막석분(tamoxifen)대CC저항적다낭란소종합정(PCOS)환자적촉배란효과.방법 장100례CC저항환자수궤분위치료조(A조)화대조조(B조).A조환자재월경제3～7천구복CG 100 mg/d,동시재월경주기적제3～7천구복타막석분40 mg/d;B조CC적응용동A조.월경제8 d개시감측란포발육정황.당유1개란포직경≥18 rmm혹2개란포직경≥17 mm시,기주hCG1 0 000 IU,36 h후성생활.관찰량조주사hCG일성숙란포수화자궁내막후도、촉배란천수、월경주기제22천잉동수평、배란솔화임신솔.결과 A조주사hCG일적성숙란포수、자궁내막후도、월경제21 d혈청중잉동수평이급배란솔화임신솔여B조상비차이균유통계학의의(P＜0.05～P＜0.01);촉배란천수조간무통계학의의(P＞0.05).결론 대CC저항적PCOS환자,타막석분가이촉진배란,개선CC대자궁내막적항자격소효응,증가자궁내막후도,제고배란솔화임신솔.
Objective To explore the effect of domoxifen combined with tamoxifen on ovulation in clomiphene-resistant patients with polycystic ovary syndrome. Methods 100 patients who was resistant to CG were randomly divided into two groups:the treatment group (group A) and control group (group B). Oral dosing CC 100mg/d to the patients of group A in the first 3th to 7th days of menses,at the same time,oral dosing tamoxifen 40mg/d in the first 3th to 7th days of menstrual cycle. The dose of CC to group B was same as group A. Beginning to monitor the case of follicular growth during the 8th day of menses. When a ovarian follicle' s diameter beyond 18mm or 2 ovarian follicle' s diameter beyond 17mm, intramuscular injection hCG 10 000IU, sexing after 36 hours later. Observing the two groups of the mature ovarian number,the endometrial thickness, the days of promoting ovulation ,the level of progesterone in serum about the 22th day of menstrual cycle, ovulation rate and pregnancy rate, after injecting hCG.Results The day after injecting hCG, the mature ovarian follicle number,the endometrial thickness, the level of progesterone in serum about the 22th day of menstrual cycle,ovulation rate and pregnancy rate,group A was significantly different from group B( P ＜0.05 ～ P ＜0. 01 ) ,the days of promoting ovulation have no statistically significant differences between the groups (P ＞ 0. 05). Conclusion In the clomiphene-resistant patients with polycystic ovary syndrome,tamoxifen could promote ovulation,improve the effect of CC on the uterus' s anti-estrogen,increase endometrial thickness, elevate ovulation rate and pregnancy rate.
