CAJ | 학술논문

目的了解2009 -2010年我国一般人群全血和尿液中铬水平(以下简称血铬、尿铬),分析其流行特点.方法于2009 -2010年,在我国内地东、中和西部8个省(市、自治区)的24个区县,采用整群随机抽样的方法抽取了11 983名6～60岁的一般人群为研究对象,对其生活环境和健康状况进行了问卷调查,并分别采集11 983份静脉抗凝血和11 853份尿样.应用电感耦合等离子体质谱法检测血铬、尿铬水平,分析不同年龄、性别和区域人群的分布情况.结果我国一般人群血铬几何均数为1.19 μg/L,中位数为1.74 μg/L,第95百分位数为5.59 μg/L;男性和女性血铬几何均数分别为1.18、1.20 μg/L(P ＞0.05)；6～ 12、12～16、16 ～20、20～ 30、30～ 45和45～60岁年龄组血铬几何均数分别为1.00、1.22、1.01、1.40、1.27和1.30 μg/L(P ＜0.01)；东、中和西部地区人群血铬几何均数分别为1.00、1.70和1.98 μg/L(P＜0.01).我国一般人群尿铬几何均值为0.53 μg/L,中位数低于检出限0.42 μg/L,第95百分位数为3.53 μg/L;男性和女性尿铬几何均值分别为0.52、0.53 μ g/L(P ＞0.05)；6～12、12 ～16、16 ～20、20～30、30～ 45和45～60岁年龄组尿铬几何均值分别为0.56、0.60、0.52、0.50、0.52和0.46 μg/L(P ＜0.01)；东、中和西部地区人群尿铬几何均数分别为0.58、＜0.42、0.60 μ g/L(P ＜0.01).结论我国一般人群血铬几何均数为1.19(1.17～1.21 )μg/L,尿铬几何均数为0.53(0.52 ～0.53) μg/L,为进一步开展铬的生物监测等研究提供了基础数据.
목적 료해2009 -2010년아국일반인군전혈화뇨액중락수평(이하간칭혈락、뇨락),분석기류행특점.방법 우2009 -2010년,재아국내지동、중화서부8개성(시、자치구)적24개구현,채용정군수궤추양적방법추취료11 983명6～60세적일반인군위연구대상,대기생활배경화건강상황진행료문권조사,병분별채집11 983빈정맥항응혈화11 853빈뇨양.응용전감우합등리자체질보법검측혈락、뇨락수평,분석불동년령、성별화구역인군적분포정황.결과 아국일반인군혈락궤하균수위1.19 μg/L,중위수위1.74 μg/L,제95백분위수위5.59 μg/L;남성화녀성혈락궤하균수분별위1.18、1.20 μg/L(P ＞0.05)；6～ 12、12～16、16 ～20、20～ 30、30～ 45화45～60세년령조혈락궤하균수분별위1.00、1.22、1.01、1.40、1.27화1.30 μg/L(P ＜0.01)；동、중화서부지구인군혈락궤하균수분별위1.00、1.70화1.98 μg/L(P＜0.01).아국일반인군뇨락궤하균치위0.53 μg/L,중위수저우검출한0.42 μg/L,제95백분위수위3.53 μg/L;남성화녀성뇨락궤하균치분별위0.52、0.53 μ g/L(P ＞0.05)；6～12、12 ～16、16 ～20、20～30、30～ 45화45～60세년령조뇨락궤하균치분별위0.56、0.60、0.52、0.50、0.52화0.46 μg/L(P ＜0.01)；동、중화서부지구인군뇨락궤하균수분별위0.58、＜0.42、0.60 μ g/L(P ＜0.01).결론 아국일반인군혈락궤하균수위1.19(1.17～1.21 )μg/L,뇨락궤하균수위0.53(0.52 ～0.53) μg/L,위진일보개전락적생물감측등연구제공료기출수거.
Objective To evaluate the chromium(Cr) levels in blood and urine among general population in China between 2009 and 2010,and thereby to analyze its prevalent features.Methods From year 2009 to 2010,a total of 11 983 subjects of general population aged between 6 and 60 year-old were recruited from 24 districts in 8 provinces in eastern,central and western China mainland,by cluster random sampling method.The information about their living environment and health status were collected by questionnaire,and 11 983 blood samples and 11 853 urine samples were also collected.Inductively coupled plasma mass spectrometry(ICP-MS) was applied to test the Cr level both in blood and urine;and the Cr distribution in blood and urine among groups of population in different ages,genders and districts,were then analyzed.Results Among general population in China,the geometric mean (GM) of Cr concentration in blood was 1.19 μg/L,with median at 1.74 μg/L and 95％ percentile at 5.59 μg/L.The Cr concentration in blood among males and females were separately 1.18 μg/L and 1.20 μg/L( P ＞ 0.05 ) ;while its GM in the groups of population aged 6 - 12,12 - 16,16 - 20,20 - 30,30 -45 and 45 - 60 years old were 1.00,1.22,1.01,1.40,1.27 and 1.30 μg/L ( P ＜ 0.01 ),respectively; and the figures in populations from eastern,central and western China were 1.00,1.70 and 1.98 μg/L( P ＜ 0.01 ),respectively.Among general population,the GM of Cr concentration in urine was 0.53 μg/L,with median was lower than 0.42μg/ L and 95％ percentile at 3.53 μg/L The Cr concentration in urine among males and females were separately 0.52 μg/L and 0.53 μg/L( P ＞ 0.05 );while its GM in the groups of population aged 6 -12,12 - 16,16 -20,20 -30,30 - 45 and 45 - 60 years old were 0.56,0.60,0.52,0.50,0.52 and 0.46 μg/L ( P ＜0.01 ),respectively; and the figures in populations from eastern,central and western China were 0.58,＜ 0.42 and 0.60 μg/L ( P ＜ 0.01 ),respectively.Conclusion The study reported the Cr levels in blood and urine among general population in China,and thereby provided basic data evidence for the following Cr biological monitoring studies in near future.