中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2009年
12期
32-33,35
,共3页
胆囊癌%p53%Ki-67
膽囊癌%p53%Ki-67
담낭암%p53%Ki-67
Gallbladder carcinoma%p53%Ki - 67
目的 探讨p53过表达和Ki-67表达与胆囊癌患者预后的相关性.方法 41例标本全部经过术后病理诊断为胆囊癌.所有患者均未行术前放化疗.由于肿瘤分期较早或者患者身体状况差等原因,所有患者仅行胆囊切除术.采用免疫组织化学ABC法检测标本中P53及Ki-67表达情况.结果 29例(71%)胆囊癌组织中p53过表达,过表达p53的患者5年生存率为17.2%,而无过表达的患者为30%,两者差异无统计学意义.24例(58.5%)胆囊癌Ki-67表达阳性,这些患者的5年生存率为9.2%,而无Ki-67表达的患者为27.7%,两者差异无统计学意叉.p53过表达和Ki-67表达与细胞分化程度及肿瘤的浸润深度均无相关性.结论 p53过表达和Ki-67表达与组织分化程度、胆囊壁浸润深度及患者的预后均无相关性.
目的 探討p53過錶達和Ki-67錶達與膽囊癌患者預後的相關性.方法 41例標本全部經過術後病理診斷為膽囊癌.所有患者均未行術前放化療.由于腫瘤分期較早或者患者身體狀況差等原因,所有患者僅行膽囊切除術.採用免疫組織化學ABC法檢測標本中P53及Ki-67錶達情況.結果 29例(71%)膽囊癌組織中p53過錶達,過錶達p53的患者5年生存率為17.2%,而無過錶達的患者為30%,兩者差異無統計學意義.24例(58.5%)膽囊癌Ki-67錶達暘性,這些患者的5年生存率為9.2%,而無Ki-67錶達的患者為27.7%,兩者差異無統計學意扠.p53過錶達和Ki-67錶達與細胞分化程度及腫瘤的浸潤深度均無相關性.結論 p53過錶達和Ki-67錶達與組織分化程度、膽囊壁浸潤深度及患者的預後均無相關性.
목적 탐토p53과표체화Ki-67표체여담낭암환자예후적상관성.방법 41례표본전부경과술후병리진단위담낭암.소유환자균미행술전방화료.유우종류분기교조혹자환자신체상황차등원인,소유환자부행담낭절제술.채용면역조직화학ABC법검측표본중P53급Ki-67표체정황.결과 29례(71%)담낭암조직중p53과표체,과표체p53적환자5년생존솔위17.2%,이무과표체적환자위30%,량자차이무통계학의의.24례(58.5%)담낭암Ki-67표체양성,저사환자적5년생존솔위9.2%,이무Ki-67표체적환자위27.7%,량자차이무통계학의차.p53과표체화Ki-67표체여세포분화정도급종류적침윤심도균무상관성.결론 p53과표체화Ki-67표체여조직분화정도、담낭벽침윤심도급환자적예후균무상관성.
Objective To investigate the interrelationship between the overexpression of p53 protein and the expression of Ki - 67 antigen and the survival of patients with gallbladder carcinoma. Methods Forty - one surgical specimens from patients with a postoperative histological diagnosis of gall-bladder carcinoma were studied. All patients were operated by simple cholecystectomy only because the turnouts were not advanced and/or their general condition was poor. The expression of p53 and Ki -67 was measured by immunohistoehemistry. Results Twenty - nine gallbladder carcinomas (71%) overex-pressed p53 protein. Five - year survival of patients with gallbladder carcinoma overexpressing p53 was 17.2%, while survival of patients without p53 overexpression was 30% (not significant). Twenty - four eases (58.5%) were considered positive for the MIB - Ⅰ index. Five - year survival of the patients with a MIB - 1 positive index was 9.2% as opposed to 27.7% for those with a negative index (not significant). There were no differenees between the grade of cell differentiation and wall infiltration. Conclusions p53 protein overexpression and Ki -67 protein expression in gallbladder carcinoma are not related to his-tological differentiation, level of gallbladder wall invasion or patient survival.
