中国呼吸与危重监护杂志
中國呼吸與危重鑑護雜誌
중국호흡여위중감호잡지
CHINESE JOURANL OF RESPIRATORY AND CRITICAL CARE MEDICINE
2009年
4期
396-398
,共3页
腹膜腔通气%机械通气%动脉血气%低氧血症%高碳酸血症%呼吸衰竭
腹膜腔通氣%機械通氣%動脈血氣%低氧血癥%高碳痠血癥%呼吸衰竭
복막강통기%궤계통기%동맥혈기%저양혈증%고탄산혈증%호흡쇠갈
Peritoneal ventilation%Mechanical ventilation%Arterial blood gas%Hypoxaemia%Hypercapnia%Respiratory failure
目的 对控制低通气造成的低氧血症伴高碳酸血症家兔,用纯氧进行腹膜腔通气,观察其对动脉血气的影响.方法 16只家兔经气管切开并插入气管导管,连接呼吸机.调整呼吸机参数,同时使用肌肉松弛剂抑制自主呼吸,造成低通气,致使兔PaO2降低和PaCO2:升高,制备低氧血症伴高碳酸血症家兔模型,然后用纯氧进行腹膜腔内通气,检测腹膜腔内通气开始后0.5、1、1.5及2 h动脉血气.结果 经纯氧腹膜腔内通气后,PaO2由通气前的(52.50±3.46)mm Hg分别显著升至腹膜腔通气后30 min的(76.46±7.79)mm Hg、1 h的(79.62±9.53)mm Hg、1.5 h的(78.54±7.18)mm Hg、2 h的(81.1±8.3)mm Hg(P均<0.05),通气各时点之间差异无统计学意义(P> 0.05).而PaCO2变化不显著(P>0.05),由(63.84±9.09)mm Hg降至腹膜腔通气后0.5 h的(59.84±14.22)mm Hg、1 h的(59.16±15.5)mm Hg、1.5 h的(60.02±7.07)mm Hg、2 h的(61.38±6.56)mm Hg.结论 用纯氧进行腹膜腔内通气能明显改善肺控制性低通气家兔的低氧血症,而对高碳酸血症改善不明显.
目的 對控製低通氣造成的低氧血癥伴高碳痠血癥傢兔,用純氧進行腹膜腔通氣,觀察其對動脈血氣的影響.方法 16隻傢兔經氣管切開併插入氣管導管,連接呼吸機.調整呼吸機參數,同時使用肌肉鬆弛劑抑製自主呼吸,造成低通氣,緻使兔PaO2降低和PaCO2:升高,製備低氧血癥伴高碳痠血癥傢兔模型,然後用純氧進行腹膜腔內通氣,檢測腹膜腔內通氣開始後0.5、1、1.5及2 h動脈血氣.結果 經純氧腹膜腔內通氣後,PaO2由通氣前的(52.50±3.46)mm Hg分彆顯著升至腹膜腔通氣後30 min的(76.46±7.79)mm Hg、1 h的(79.62±9.53)mm Hg、1.5 h的(78.54±7.18)mm Hg、2 h的(81.1±8.3)mm Hg(P均<0.05),通氣各時點之間差異無統計學意義(P> 0.05).而PaCO2變化不顯著(P>0.05),由(63.84±9.09)mm Hg降至腹膜腔通氣後0.5 h的(59.84±14.22)mm Hg、1 h的(59.16±15.5)mm Hg、1.5 h的(60.02±7.07)mm Hg、2 h的(61.38±6.56)mm Hg.結論 用純氧進行腹膜腔內通氣能明顯改善肺控製性低通氣傢兔的低氧血癥,而對高碳痠血癥改善不明顯.
목적 대공제저통기조성적저양혈증반고탄산혈증가토,용순양진행복막강통기,관찰기대동맥혈기적영향.방법 16지가토경기관절개병삽입기관도관,련접호흡궤.조정호흡궤삼수,동시사용기육송이제억제자주호흡,조성저통기,치사토PaO2강저화PaCO2:승고,제비저양혈증반고탄산혈증가토모형,연후용순양진행복막강내통기,검측복막강내통기개시후0.5、1、1.5급2 h동맥혈기.결과 경순양복막강내통기후,PaO2유통기전적(52.50±3.46)mm Hg분별현저승지복막강통기후30 min적(76.46±7.79)mm Hg、1 h적(79.62±9.53)mm Hg、1.5 h적(78.54±7.18)mm Hg、2 h적(81.1±8.3)mm Hg(P균<0.05),통기각시점지간차이무통계학의의(P> 0.05).이PaCO2변화불현저(P>0.05),유(63.84±9.09)mm Hg강지복막강통기후0.5 h적(59.84±14.22)mm Hg、1 h적(59.16±15.5)mm Hg、1.5 h적(60.02±7.07)mm Hg、2 h적(61.38±6.56)mm Hg.결론 용순양진행복막강내통기능명현개선폐공제성저통기가토적저양혈증,이대고탄산혈증개선불명현.
Objective To observe the effects of peritoneal ventilation with pure oxygen in the rabbits with hypoxaemia and hypercapnia induced by mechanical controlled hypoventilation.Methods Sixteen rabbits were invasive|y ventilated after trachea incision.Hypoxaemia and hypercapnia were induced by hypoventilation which was implemented both by degrading ventilation parameters and respiratory depression induced by intravenous infusion of muscle relaxant.Then pure oxygen was insufflated into the peritoneal cavity and arterial blood gases were measured every 30 minutes for two hours.Results The PaO2 was (52.50±3.46)mm Hg at baseline and increased to (76.46±7.79) mm Hg, (79.62±9.53) mm Hg, (78.54±7.18) mm Hg, and (81.1±8.3) mm Hg, respectively at 30,60,90, and 120 minutes after the peritoneal ventilation with pure oxgen (all P < 0.05).Meanwhile PaCO2 was (63.84±9.09)mm Hg at baseline and (59.84±14.22) mm Hg, (59.16±15.5) mm Hg, (60.02±7.07) mm Hg, and (61.38± 6.56)mm Hg, respectively at 30,60,90, and 120 minutes after the peritoneal ventilation with pure oxgen with no significant change (P > 0.05).Conclusion Peritoneal ventilation can obviously improve hypoxaemia induced by mechanical controlled hypoventilation, whereas hypercapnia remains unchanged.
