中国生化药物杂志
中國生化藥物雜誌
중국생화약물잡지
CHINESE JOURNAL OF BIOCHEMICAL PHARMACEUTICS
2009年
6期
397-399,403
,共4页
何晓瑾%彭计红%何晓冬%夏卫军
何曉瑾%彭計紅%何曉鼕%夏衛軍
하효근%팽계홍%하효동%하위군
仙葛颗粒%骨质疏松%骨密度%骨代谢%微结构
仙葛顆粒%骨質疏鬆%骨密度%骨代謝%微結構
선갈과립%골질소송%골밀도%골대사%미결구
Xiange Granule%osteoporosis%bone mineral density%bone metabolism%microstructure
目的 观察仙葛颗粒对去卵巢骨质疏松大鼠模型的影响,探究其防治骨质疏松症的机制.方法 将60只雌性大鼠随机分成空白对照组,模型组,仙葛颗粒低、中、高剂量组,尼尔雌醇组共6组.采用卵巢切除的方法制成绝经后骨质疏松动物模型,灌胃给药3个月后测定股骨骨密度及降钙素、骨钙素、雌二醇含量,取股骨下段松质骨进行电镜观察.结果 仙葛颗粒能明显提高去卵巢大鼠模型血清降钙素、骨钙素和雌二醇水平,显著增加其骨密度值,改善松质骨的微结构.结论 仙葛颗粒对骨质疏松症有防治作用.
目的 觀察仙葛顆粒對去卵巢骨質疏鬆大鼠模型的影響,探究其防治骨質疏鬆癥的機製.方法 將60隻雌性大鼠隨機分成空白對照組,模型組,仙葛顆粒低、中、高劑量組,尼爾雌醇組共6組.採用卵巢切除的方法製成絕經後骨質疏鬆動物模型,灌胃給藥3箇月後測定股骨骨密度及降鈣素、骨鈣素、雌二醇含量,取股骨下段鬆質骨進行電鏡觀察.結果 仙葛顆粒能明顯提高去卵巢大鼠模型血清降鈣素、骨鈣素和雌二醇水平,顯著增加其骨密度值,改善鬆質骨的微結構.結論 仙葛顆粒對骨質疏鬆癥有防治作用.
목적 관찰선갈과립대거란소골질소송대서모형적영향,탐구기방치골질소송증적궤제.방법 장60지자성대서수궤분성공백대조조,모형조,선갈과립저、중、고제량조,니이자순조공6조.채용란소절제적방법제성절경후골질소송동물모형,관위급약3개월후측정고골골밀도급강개소、골개소、자이순함량,취고골하단송질골진행전경관찰.결과 선갈과립능명현제고거란소대서모형혈청강개소、골개소화자이순수평,현저증가기골밀도치,개선송질골적미결구.결론 선갈과립대골질소송증유방치작용.
Purpose To observe the effect of Xiange Granule on osteoporosis in ovariectomized rat model and explore the mechanism of prevention and treatment of osteoporosis.Methods 60 female rats were randomly divided into blank control group, model group, Xiange Granule low, middle and high-dose group, CEE3 group of 6 groups. The method used ovariectomy made animal model of postmenopausal osteoporosis. Gavage after 3 months measured femur bone mineral density, calcitonin, bone gla protein and estradiol concentration, observed cancellous bone of femur with electron microscope.Results Xiange Granule could significantly increase the bone mineral density, calcitonin, bone gla protein and estradiol levels of the ovariectomized rat model and improve the microstructure of cancellous bone.Conclusion Xiange Granule is effective for prevention and treatment on osteoporosis.
