CAJ | 학술논문

在心血管支架表面构建仿生细胞外基质结构的涂层是提高支架生物相客性的有效方法.结合静电纺丝及静电自组装技术,在316L医用不锈钢基底上制备出网状聚氨酯/(羧甲基壳聚糖/壳聚糖)_n复合涂层.血小板黏附实验表明,对于网状聚氨酯涂层,血小板较易黏附在直径小于1μm的纤维上,在直径大于1 μm的纤维上几乎无血小板黏附;而聚氨酯/(羧甲基壳聚糖/壳聚糖)_n复合涂层的血小板黏附数量明显下降,血液相容性得到改善.
재심혈관지가표면구건방생세포외기질결구적도층시제고지가생물상객성적유효방법.결합정전방사급정전자조장기술,재316L의용불수강기저상제비출망상취안지/(최갑기각취당/각취당)_n복합도층.혈소판점부실험표명,대우망상취안지도층,혈소판교역점부재직경소우1μm적섬유상,재직경대우1 μm적섬유상궤호무혈소판점부;이취안지/(최갑기각취당/각취당)_n복합도층적혈소판점부수량명현하강,혈액상용성득도개선.
Biomimetic extracellular matrix-like coatings on the surface of cardiovascular stents are effective in improving the blood compatibility. Fibrous polyurethane/(carboxymethyl chitosan / chitosan)_n composite coatings were fabricated on the substrates of 316L stainless steel by coupling an electrospinning process with an electrostatic self-assembling process. The polyurethane fibrous coatings platelet adhesion tests show that there is severe platelets adhesion on the fibers below 1 μm diameter,but there is almost no platelets adhesion on the fibers above 1 μm diameter. Furthermore,the number of platelets adhesion on the polyurethane/(carboxymethyl chitosan/chitosan)_n composite coatings decreases obviously, and the composite coatings present good blood compatibility.