CAJ | 학술논문

目的对过期妊娠无产兆孕妇进行外周血T淋巴细胞亚群和NK细胞的观察,观察过期妊娠与母体细胞免疫是否有关.方法选择过期妊娠无产兆孕妇100例为过期组,同时选择孕37～41周先兆临产孕妇100例为对照组.对两组孕妇外周血T淋巴亚群和NK细胞进行测定,同时行血常规检查,结合外周血白细胞计数计算其百分比.结果正常先兆临产组和过期妊娠组比较,淋巴细胞在妊娠期总数差异无显著性(P＞0.05);CD8+、CD3+所占百分比两组孕妇相比,数值差异均无显著性(P＞0.05);但过期妊娠组孕妇CD4+明显下降[(35.42140±3.47213)%vs(40.64890±8.39074)%].两组比较差异有显著性(P=0.036):过期妊娠组孕妇CD4+/CD8+显著下降[(1.12000±O.23508)vs(1.61220±O.61741)],两组比较差异有显著性(P=0.009);NK细胞两组比较差异无显著性(P=0.834).结论过期妊娠孕妇和正常先兆临产孕妇比较,过期妊娠孕妇外周血CD4+淋巴细胞数量和CD4+/CD8+比值显著低于正常孕妇,过期妊娠可能与细胞免疫功能改变有关.
목적 대과기임신무산조잉부진행외주혈T림파세포아군화NK세포적관찰,관찰과기임신여모체세포면역시부유관.방법 선택과기임신무산조잉부100례위과기조,동시선택잉37～41주선조임산잉부100례위대조조.대량조잉부외주혈T림파아군화NK세포진행측정,동시행혈상규검사,결합외주혈백세포계수계산기백분비.결과 정상선조임산조화과기임신조비교,림파세포재임신기총수차이무현저성(P＞0.05);CD8+、CD3+소점백분비량조잉부상비,수치차이균무현저성(P＞0.05);단과기임신조잉부CD4+명현하강[(35.42140±3.47213)%vs(40.64890±8.39074)%].량조비교차이유현저성(P=0.036):과기임신조잉부CD4+/CD8+현저하강[(1.12000±O.23508)vs(1.61220±O.61741)],량조비교차이유현저성(P=0.009);NK세포량조비교차이무현저성(P=0.834).결론 과기임신잉부화정상선조임산잉부비교,과기임신잉부외주혈CD4+림파세포수량화CD4+/CD8+비치현저저우정상잉부,과기임신가능여세포면역공능개변유관.
Objective To study the expressions of T cell subsets and NK cells in peripheral blood of postterm pregnancy without symptoms of labor.And to explore the relationship between postterm pregnancy and maternal cell immune function.Methods The plasma levels of t cell subsets and NK cells were detected by using flow cytometry in 100 patients with postterm pregnancy and 100 patients with threatened labor from 37 weeks to 41 weeks.And their propo~ions were calculled with the WBC of blood routine.Results The proportion of NK cell,CD3+,CD8+in the experimental group were lower than those of the control group.There is no significant difference(P＞0.05)between them;CD4+,CD4+/CD8+are significantly lower than those of the control group(P＜0.05).Conclusion The immune function of the patients with postterm pregnancy is significantly lower than that of the normal labor.