中华麻醉学杂志
中華痳醉學雜誌
중화마취학잡지
CHINESE JOURNAL OF ANESTHESIOLOGY
2009年
3期
236-239
,共4页
王本福%金胜威%赖苗军%唐甩恩%曹红%林函%周文华%张富强%李军%朱华强%连庆泉
王本福%金勝威%賴苗軍%唐甩恩%曹紅%林函%週文華%張富彊%李軍%硃華彊%連慶泉
왕본복%금성위%뢰묘군%당솔은%조홍%림함%주문화%장부강%리군%주화강%련경천
二异丙酚%物质滥用,静脉内
二異丙酚%物質濫用,靜脈內
이이병분%물질람용,정맥내
Propofol%Substance abuse,intravenous
目的 评价异丙酚是否可诱发大鼠精神依赖性.方法 清洁级雄性SD大鼠24只,体重240～270 g,周龄14周,麻醉下右颈外静脉置管,7d后开始连续14 d的自身给药实验.随机分为4组(n=6):脂肪乳对照组(C组)、异丙酚0.56 rag/ks组(P1组)、异丙酚1.00 mg,kg组(P2组)和异丙酚1.70 rag/ks组(P1组).实验由计算机控制,每天限定最高注射次数为50次,P1组、P2组和P3组每次分别静脉注射异丙酚0.56、1.00、1.70 mg/kg,C组静脉注射脂肪乳0.1ml/kg.记录大鼠每天有效鼻触次数、无效鼻触次数、注射药物次数及最后3d异丙酚日注射量.结果 与C组和P1组比较,P2组和P1组有效鼻触次数和注射药物次数增加(P<0.01);与P2组比较,P3组有效鼻触次数和注射药物次数增加(P<0.01).C组与P1组有效鼻触次数和注射药物次数比较差异无统计学意义(P>0.05);4组间无效鼻触次数比较差异无统计学意义(P>0.05).P1组、P2组和P3组最后3d异丙酚日注射量呈剂量依赖性(P<0.01).结论 异丙酚诱发大鼠精神依赖性,与其剂量有关.
目的 評價異丙酚是否可誘髮大鼠精神依賴性.方法 清潔級雄性SD大鼠24隻,體重240～270 g,週齡14週,痳醉下右頸外靜脈置管,7d後開始連續14 d的自身給藥實驗.隨機分為4組(n=6):脂肪乳對照組(C組)、異丙酚0.56 rag/ks組(P1組)、異丙酚1.00 mg,kg組(P2組)和異丙酚1.70 rag/ks組(P1組).實驗由計算機控製,每天限定最高註射次數為50次,P1組、P2組和P3組每次分彆靜脈註射異丙酚0.56、1.00、1.70 mg/kg,C組靜脈註射脂肪乳0.1ml/kg.記錄大鼠每天有效鼻觸次數、無效鼻觸次數、註射藥物次數及最後3d異丙酚日註射量.結果 與C組和P1組比較,P2組和P1組有效鼻觸次數和註射藥物次數增加(P<0.01);與P2組比較,P3組有效鼻觸次數和註射藥物次數增加(P<0.01).C組與P1組有效鼻觸次數和註射藥物次數比較差異無統計學意義(P>0.05);4組間無效鼻觸次數比較差異無統計學意義(P>0.05).P1組、P2組和P3組最後3d異丙酚日註射量呈劑量依賴性(P<0.01).結論 異丙酚誘髮大鼠精神依賴性,與其劑量有關.
목적 평개이병분시부가유발대서정신의뢰성.방법 청길급웅성SD대서24지,체중240～270 g,주령14주,마취하우경외정맥치관,7d후개시련속14 d적자신급약실험.수궤분위4조(n=6):지방유대조조(C조)、이병분0.56 rag/ks조(P1조)、이병분1.00 mg,kg조(P2조)화이병분1.70 rag/ks조(P1조).실험유계산궤공제,매천한정최고주사차수위50차,P1조、P2조화P3조매차분별정맥주사이병분0.56、1.00、1.70 mg/kg,C조정맥주사지방유0.1ml/kg.기록대서매천유효비촉차수、무효비촉차수、주사약물차수급최후3d이병분일주사량.결과 여C조화P1조비교,P2조화P1조유효비촉차수화주사약물차수증가(P<0.01);여P2조비교,P3조유효비촉차수화주사약물차수증가(P<0.01).C조여P1조유효비촉차수화주사약물차수비교차이무통계학의의(P>0.05);4조간무효비촉차수비교차이무통계학의의(P>0.05).P1조、P2조화P3조최후3d이병분일주사량정제량의뢰성(P<0.01).결론 이병분유발대서정신의뢰성,여기제량유관.
Objective To assess whether propofol call induce stable psychic dependence in the rats by self-administration experiment. Methods Twenty-four male SD rats 14 weeks old weighing 240一270 mg were studied. Anesthesia was performed with intraperitoneal injection of 3%sodium pentoharbitsl 40 ms/kg and atropine 03 mg/kg.A catheter wag inserted into the right external jugular vein. Penicillin(100 000 U)0.2 ml wag injected through the external jugular vein for anti-infection and heparin sodium(50U/ml)0.1 ml for anticoagulation. The self-administration experiment of 14 days was started after the 7 days of recovery. All the rats were randomly divided into 4 groups(n=6 each):contontrol group(C),propofol 0.56 mg/kg/l group(P1),propofol 1.00 mg/kg group(P2)and pmpofol 1.70 ms/kg group(P3).The experimental events were controlled by a computer with 50 times of the maximum injection per day.The times ofactive and inactive nose-poke response and times of drug iniection were recorded per day.Results Compared with group C and P1,the times of active nosepoke response and injections were significantly increased in group P2 and P3(P<0.01).The times of active nosepoke response and injections per day were significantly increased in group P3 than in group P2(P(0.01).There was no significant difference in the times of active nose-poke response and injections between group C and P1.There was no significant difference in inactive nose-poke resporme between the 4 groups.And the total daily doses of propofol injected in the last 3 days were significantly increased in a dose-dependent manner.Conclusion Propefol can induce the development of psychological dependence in rata and it is related to the dosage.
