CAJ | 학술논문

目的了解中国围产儿腹裂畸形的发生情况,并分析其相关因素.方法以医院为基础的出生缺陷监测方法收集资料,利用趋势x2检验对1996-2007年中国围产儿腹裂畸形患病率变化趋势进行研究、泊松回归模型对几个主要影响腹裂围产儿分布的因素进行危险度分析.结果共监测新生儿6 308 594例,其中腹裂畸形1601例,总患病率为2.54/万,12年内没有显著增长趋势.城乡、男女及孕产妇不同年龄组之间患病率的差异均有统计学意义,城市患病率(1.91/万)低于农村(3.87/万),男性患病率(2.20/万)低于女性(2.62/万),孕产妇年龄＜20岁组患病率(10.38/万)高于其他各年龄组患病率.城市腹裂畸形患病率低于农村(RR=0.58);男性腹裂畸形患病率低于女性(RR=0.76);孕产妇年龄＜20岁组围产儿腹裂患病率是30～34岁组的11.43倍(RR=11.432).结论 1996-2007年中国围产儿腹裂患病率没有显著增长,但在性别、城乡及产妇年龄之间存在差异.年龄＜20岁的产妇生育腹裂胎儿的危险性最大.
목적 료해중국위산인복렬기형적발생정황,병분석기상관인소.방법 이의원위기출적출생결함감측방법수집자료,이용추세x2검험대1996-2007년중국위산인복렬기형환병솔변화추세진행연구、박송회귀모형대궤개주요영향복렬위산인분포적인소진행위험도분석.결과 공감측신생인6 308 594례,기중복렬기형1601례,총환병솔위2.54/만,12년내몰유현저증장추세.성향、남녀급잉산부불동년령조지간환병솔적차이균유통계학의의,성시환병솔(1.91/만)저우농촌(3.87/만),남성환병솔(2.20/만)저우녀성(2.62/만),잉산부년령＜20세조환병솔(10.38/만)고우기타각년령조환병솔.성시복렬기형환병솔저우농촌(RR=0.58);남성복렬기형환병솔저우녀성(RR=0.76);잉산부년령＜20세조위산인복렬환병솔시30～34세조적11.43배(RR=11.432).결론 1996-2007년중국위산인복렬환병솔몰유현저증장,단재성별、성향급산부년령지간존재차이.년령＜20세적산부생육복렬태인적위험성최대.
Objective To investigate the incidence and its secular trends of gastroschisis in Chinese perinatal infants.Methods Data on perinatal infants was collected at hospitals under surveillance program in Chinese Birth Defects Monitoring Network from 1996 to 2007.Data on incidence,trend and related factors of gastroschisis in perinatal infants were carried out.Both x2 test and Poisson regression model were used to test the differences between residential areas,sex and maternal age.Both x2 trends test and Poisson regression model were applied to analyze the trends.Results A total of 6 308 594 perinatal infants were monitored during 1996-2007,including 1601 infants with gastroschisis to show the incidence as 2.54 per 10 000 births.The overall prevalence of gastroschisis in China did not change remarkably during the period of our research.The incidence rates of gastroschisis were significantly different between urban and rural areas,between different sex and different maternal age groups.The incidence of gastroschisis was lower in urban area than in rural area (RR=0.58) and lower in female fetuses than in male fetuses (RR=0.76),highest in the group younger than 20 years of age,which was 11.43 times than incidence of the 30-34 age group (RR=11.432).Conclusion The overall prevalence of gastroschisis in China did not show remarkable change during 1996-2007 but the incidence of gastroschisis a bit increased in the area of study and significant differences were seen in different sex,regions and maternal age groups.Mothers aged younger than 20 years old appeared to be a significant risk factor for the occurrence of gastroschisis.