中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2011年
1期
14-16
,共3页
孙艳荪%乔珊%史嵘%曾文双%钟霞%陈东燕%邓远飞
孫豔蓀%喬珊%史嶸%曾文雙%鐘霞%陳東燕%鄧遠飛
손염손%교산%사영%증문쌍%종하%진동연%산원비
睡眠呼吸暂停综合征%糖代谢异常%多导睡眠图%胰岛素抵抗%低氧血症
睡眠呼吸暫停綜閤徵%糖代謝異常%多導睡眠圖%胰島素牴抗%低氧血癥
수면호흡잠정종합정%당대사이상%다도수면도%이도소저항%저양혈증
Obstructive sleep apnea syndrome%Abnormal glucose metabolism%Polysemnography%Insulin resistance%Hypoxemia
目的 研究阻塞性睡眠呼吸暂停低通气综合征(OSAHS)对胰岛素抵抗(IR)程度及糖代谢的影响.方法 选择确诊无糖尿病病史的OSAHS患者58例,另选57例无糖尿病病史非OSAHS患者作为对照组,OSAHS组患者经多导睡眠监测仪8 h睡眠监测,区分为中、重度OSAHS组51例,其中中度OSAHS组21例,重度OSAHS组30例;轻度OSAHS组7例.所有患者均行75 g葡萄糖耐量试验,采用胰岛素稳定状态模式评估方法(HOMA)指数评估IR,比较不同组别HOMA指数及糖代谢紊乱发生情况.结果 ①OSAHS组的HOMA-IR明显高于非OSAHS组,OSAHS组平均和最低脉搏氧饱和度(SpO2)明显低于非OSAHS组,上述指标在两组间比较差异均有统计学意义(P<0.05),HOMA-IR指数和AHI呈正相关,和最低SpO2存在负相关.②OSAHS组的糖代谢紊乱的发生率明显高于非OSAHS组,且随着OSAHS程度的加重,糖代谢紊乱的发生率明显增加(P<0.01).结论 睡眠呼吸功能紊乱与胰岛素抵抗及糖代谢异常的发生有关,在OSAHS患者中,随着呼吸紊乱程度加重,IR加重,糖代谢紊乱的发生率明显增加.
目的 研究阻塞性睡眠呼吸暫停低通氣綜閤徵(OSAHS)對胰島素牴抗(IR)程度及糖代謝的影響.方法 選擇確診無糖尿病病史的OSAHS患者58例,另選57例無糖尿病病史非OSAHS患者作為對照組,OSAHS組患者經多導睡眠鑑測儀8 h睡眠鑑測,區分為中、重度OSAHS組51例,其中中度OSAHS組21例,重度OSAHS組30例;輕度OSAHS組7例.所有患者均行75 g葡萄糖耐量試驗,採用胰島素穩定狀態模式評估方法(HOMA)指數評估IR,比較不同組彆HOMA指數及糖代謝紊亂髮生情況.結果 ①OSAHS組的HOMA-IR明顯高于非OSAHS組,OSAHS組平均和最低脈搏氧飽和度(SpO2)明顯低于非OSAHS組,上述指標在兩組間比較差異均有統計學意義(P<0.05),HOMA-IR指數和AHI呈正相關,和最低SpO2存在負相關.②OSAHS組的糖代謝紊亂的髮生率明顯高于非OSAHS組,且隨著OSAHS程度的加重,糖代謝紊亂的髮生率明顯增加(P<0.01).結論 睡眠呼吸功能紊亂與胰島素牴抗及糖代謝異常的髮生有關,在OSAHS患者中,隨著呼吸紊亂程度加重,IR加重,糖代謝紊亂的髮生率明顯增加.
목적 연구조새성수면호흡잠정저통기종합정(OSAHS)대이도소저항(IR)정도급당대사적영향.방법 선택학진무당뇨병병사적OSAHS환자58례,령선57례무당뇨병병사비OSAHS환자작위대조조,OSAHS조환자경다도수면감측의8 h수면감측,구분위중、중도OSAHS조51례,기중중도OSAHS조21례,중도OSAHS조30례;경도OSAHS조7례.소유환자균행75 g포도당내량시험,채용이도소은정상태모식평고방법(HOMA)지수평고IR,비교불동조별HOMA지수급당대사문란발생정황.결과 ①OSAHS조적HOMA-IR명현고우비OSAHS조,OSAHS조평균화최저맥박양포화도(SpO2)명현저우비OSAHS조,상술지표재량조간비교차이균유통계학의의(P<0.05),HOMA-IR지수화AHI정정상관,화최저SpO2존재부상관.②OSAHS조적당대사문란적발생솔명현고우비OSAHS조,차수착OSAHS정도적가중,당대사문란적발생솔명현증가(P<0.01).결론 수면호흡공능문란여이도소저항급당대사이상적발생유관,재OSAHS환자중,수착호흡문란정도가중,IR가중,당대사문란적발생솔명현증가.
Objective To study the influence of obstructive sleep apnea syndrome (OSAS)to the development of abnormal glucose metabolism and insulin insistence. Methods Fifty - eight OSAHS patient and 57 normal volunteers were measured by polysomnograpby during sleep and 75 g oral glucose tolerance test, then compared the homeostasis model assessment(HOMA) index and abnormal glucose metabolism frequency. Results ①HOMA - IR of OSAHS group were significantly higher than that in the control group( P < 0. 05 ), HOMA index were positively correlated with AHI and negatively correlated with the nocturnal lowest SpO2 respectively with statistical significance.②The frequency of abnormal glucose metabolism in OSAHS group were significantly higher than that in the control group( P <0. 01 ).Conclusions The extent of respiratory disturbance is closely related with insulin resistance and abnormal glucose metabolism. Insulin resistance inclined and the frequency of abnormal glucose metabolismn more higher accompany with the respiratory disturbance increased in OSAHS.
