CAJ | 학술논문

目的探讨供受者HLA致敏原性错配(IM)对肾移植受者急性排斥反应发生率的影响.方法回顾性分析196例首次肾移植受者IM对肾移植术后肾功能恢复时间及1年内排斥反应发生率的影响.结果IM对肾移植术后肾功能恢复时间无明显影响;IM患者1年内急性排斥反应发生率明显增加,各类位点IM对肾移植术后急性排斥的影响比较,A位点影响不大,B位点与急性排斥有关,DR位点IM可致急性排斥明显增加.结论在临床采用HLA氨基酸残基配型标准判断组织配型的同时,IM不容忽视,HLA-B位点IM与肾移植术后急性排斥反应相关,HLA-DR位点IM明显影响肾移植术后急性排斥反应发生率.
목적탐토공수자HLA치민원성착배(IM)대신이식수자급성배척반응발생솔적영향.방법회고성분석196례수차신이식수자IM대신이식술후신공능회복시간급1년내배척반응발생솔적영향.결과IM대신이식술후신공능회복시간무명현영향;IM환자1년내급성배척반응발생솔명현증가,각류위점IM대신이식술후급성배척적영향비교,A위점영향불대,B위점여급성배척유관,DR위점IM가치급성배척명현증가.결론재림상채용HLA안기산잔기배형표준판단조직배형적동시,IM불용홀시,HLA-B위점IM여신이식술후급성배척반응상관,HLA-DR위점IM명현영향신이식술후급성배척반응발생솔.
Objective To investigate the influence of HLA immunogenic mismatching (IM) on acute rejection of renal transplants.Methods The function recovery time of renal allograft and the rate of acute rejection of 196 cases after cadaveric renal transplantation wereanalyzed. Results IM of HLA locus did not influence the function recovery time of the renal allograft. The IM of HLA-A locus did not increase the rate of allograft acute rejection whereas the HLA-B locus did and the HLA-DR increased the acute rejection rate significantly. Conclusion IM should not be ignored in HLA typing. HLA-B locus is related to the allograft acute rejection, while the IM of DR locus increasesthe allograft acute rejection rate significantly.