CAJ | 학술논문

目的探讨心脏型脂肪酸结合蛋白(H-FABP)在急性心肌梗死(AMI)早期诊断中的临床应用价值.方法将来本院的AMI疑似患者156例,按就诊时发病时间分为2组,分别在发病后0～3、3～6 h内同时检测H-FABP、肌钙蛋白T(cTnT)、肌酸激酶同工酶(CK-MB).计算各项指标的灵敏度、特异性、准确度,并进行比较分析.结果 H-FABP在发病0～3 h内诊断的灵敏度为70.7%,特异性为97.0%,准确度为82.4%,显著高于cTnT和CK-MB,差异有统计学意义(P<0.05).在发病3～6 h内诊断的灵敏度为100.0%,显著高于cTnT,差异有统计学意义(P<0.05),特异性为92.6%,准确度为97.6%.结论 H-FABP是AMI早期诊断最敏感的指标,具有非常重要的临床应用价值.
목적 탐토심장형지방산결합단백(H-FABP)재급성심기경사(AMI)조기진단중적림상응용개치.방법 장래본원적AMI의사환자156례,안취진시발병시간분위2조,분별재발병후0～3、3～6 h내동시검측H-FABP、기개단백T(cTnT)、기산격매동공매(CK-MB).계산각항지표적령민도、특이성、준학도,병진행비교분석.결과 H-FABP재발병0～3 h내진단적령민도위70.7%,특이성위97.0%,준학도위82.4%,현저고우cTnT화CK-MB,차이유통계학의의(P<0.05).재발병3～6 h내진단적령민도위100.0%,현저고우cTnT,차이유통계학의의(P<0.05),특이성위92.6%,준학도위97.6%.결론 H-FABP시AMI조기진단최민감적지표,구유비상중요적림상응용개치.
Objective To study the clinical value of heart-type fatty acid-binding protein (H-FABP) in early diagnosis of acute myocardial infarction(AMI). Methods Totally 156 patients who were suspicious to be AMI were divided into group A (0～3 h group) and group B (3～6 h group) ac-cording to the visit time. H-FABP,cardiae troponin T (cTnT) and cardiac troponin T (cTnT);Crea-fine kinase isoenzyme-MB (CK-MB) were simultaneously measured at different time-points. The sensi-tivity,specificity and accuracy of the markers were calculated and compared. Results The sensitivity, specificity and accuracy of H-FABP were all the highest among three tumor markers;the sensitivity within 3 hours was 70.7% ,higher than that of cTnT and CK-MB remarkably (P<0.05);the specific-ity was 97.0%; the accuracy was 82.4%, higher than that of cTnT and CK-MB remarkably (P<0.05);while the sensitivity within 3～6 hours was 100.0%, higher than that of cTnT remarkably (P <0.05);the specificity was 92.6%;and the accuracy was 97.6%. Conclusion H-FABP is the most sensitive indicator for early diagnosis of AMI and is of very important value in clinical application.