中国临床药理学杂志
中國臨床藥理學雜誌
중국림상약이학잡지
THE CHINESE JOURNAL OF CLINICAL PHARMACOLOGY
2010年
2期
110-113
,共4页
郭涛%孙昨明%夏东亚%郑谊%肖勇%王宁芹%郭红亮%刘鹏
郭濤%孫昨明%夏東亞%鄭誼%肖勇%王寧芹%郭紅亮%劉鵬
곽도%손작명%하동아%정의%초용%왕저근%곽홍량%류붕
奥美拉唑%反相高效液相色谱法%药代动力学%汉族人%回族人
奧美拉唑%反相高效液相色譜法%藥代動力學%漢族人%迴族人
오미랍서%반상고효액상색보법%약대동역학%한족인%회족인
omeprazole%RP-HPLC%pharmacokinetics%Chinese Han%Chinese Hui
目的 研究奥美拉唑肠溶片(抗溃疡药)在回族和汉族健康受试者的药代动力学.方法 健康回族和汉族受试者各1O名,男、女各半,单剂量口服奥美拉唑肠溶片40 mg后,用反相高效液相色谱法测定人血浆中奥美拉唑的浓度.用DAS 2.0药代动力学软件进行数据处理,SPSS 11.5软件进行统计分析.结果 回族和汉族受试者的主要药代动力学参数:C_(max)分别为(941.94±446.08)和(760.49±581.23) μg·L~(-1);t_(max)分别为(2.7±0.68)和(2.70±0.82)h;t_(1/2)分别为(2.43±2.83)和(1.60±1.28)h;AUC_(0-12)分别为(2.29±1.12)和(1.44±7.98)mg·h·L~(-1);AUC_(0-∞) 分别为(2.33±1.11)和(1.47±7.69)mg·h·L~(-1).结论 回族、汉族受试者的c_(max),AUC_(0_12),AUC_(0-∞)个体间差异较大;但2民族主要药代动力学参数差异无统计学意义.
目的 研究奧美拉唑腸溶片(抗潰瘍藥)在迴族和漢族健康受試者的藥代動力學.方法 健康迴族和漢族受試者各1O名,男、女各半,單劑量口服奧美拉唑腸溶片40 mg後,用反相高效液相色譜法測定人血漿中奧美拉唑的濃度.用DAS 2.0藥代動力學軟件進行數據處理,SPSS 11.5軟件進行統計分析.結果 迴族和漢族受試者的主要藥代動力學參數:C_(max)分彆為(941.94±446.08)和(760.49±581.23) μg·L~(-1);t_(max)分彆為(2.7±0.68)和(2.70±0.82)h;t_(1/2)分彆為(2.43±2.83)和(1.60±1.28)h;AUC_(0-12)分彆為(2.29±1.12)和(1.44±7.98)mg·h·L~(-1);AUC_(0-∞) 分彆為(2.33±1.11)和(1.47±7.69)mg·h·L~(-1).結論 迴族、漢族受試者的c_(max),AUC_(0_12),AUC_(0-∞)箇體間差異較大;但2民族主要藥代動力學參數差異無統計學意義.
목적 연구오미랍서장용편(항궤양약)재회족화한족건강수시자적약대동역학.방법 건강회족화한족수시자각1O명,남、녀각반,단제량구복오미랍서장용편40 mg후,용반상고효액상색보법측정인혈장중오미랍서적농도.용DAS 2.0약대동역학연건진행수거처리,SPSS 11.5연건진행통계분석.결과 회족화한족수시자적주요약대동역학삼수:C_(max)분별위(941.94±446.08)화(760.49±581.23) μg·L~(-1);t_(max)분별위(2.7±0.68)화(2.70±0.82)h;t_(1/2)분별위(2.43±2.83)화(1.60±1.28)h;AUC_(0-12)분별위(2.29±1.12)화(1.44±7.98)mg·h·L~(-1);AUC_(0-∞) 분별위(2.33±1.11)화(1.47±7.69)mg·h·L~(-1).결론 회족、한족수시자적c_(max),AUC_(0_12),AUC_(0-∞)개체간차이교대;단2민족주요약대동역학삼수차이무통계학의의.
Objective To study the pharmacokinetics of omeprazole tablets in Chinese Hui and Han healthy volunteers.Methods Twenty volunteers were involved in the study,including ten Chinese Hui volunteers and ten Han volunteers.Each healthy volunlteers were given asingle oral dose(40 mg)of omeprazole tablet.The concentration of omeprazole in plasma was determined by RP-HPLC and the pharameters were calculated by DAS 2.0 software.Results The main pharmacokinetic parameters of Chinese Hui and Han were as follows:C_(max) were (941.94±446.08) and (760.49±581.23) μg·L~(-1);t_(max) were(2.7±0.68)and(2.70±0.82)h;t_(1/2) were(2.43±2.83)and(1.60±1.28)h;AUC_(0-12) were (2.29±1.12)and(1.44±7.98)mg·h·L~(-1);AUC_(0-∞) were (2.33±1.11)and(1.47±7.69)mg·h·L~(-1),respectively.Conclusion Individual difference is significant in C_(max),AUC_(0-12),AUC_(0-∞) after an oral omeprazole,but the pharmacokinetic parameters obtained from the results of ststistical analysis show no significant difference in the main pharmacokinetic of omeprazole between Chinese Hui and Han.
